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Ingestion of single guide RNAs induces gene overexpression and extends lifespan in Caenorhabditis elegans via CRISPR activation

Inhibition of gene expression in Caenorhabditis elegans, a versatile model organism for studying the genetics of development and aging, is achievable by feeding nematodes with bacteria expressing specific dsRNAs. Overexpression of hypoxia-inducible factor 1 (hif-1) or heat-shock factor 1 (hsf-1) by...

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Detalles Bibliográficos
Autores principales:	Fischer, Fabian, Benner, Christoph, Goyala, Anita, Grigolon, Giovanna, Vitiello, Davide, Wu, JiaYee, Zarse, Kim, Ewald, Collin Y., Ristow, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243178/ https://www.ncbi.nlm.nih.gov/pubmed/35636511 http://dx.doi.org/10.1016/j.jbc.2022.102085

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