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Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements

Several common pharmaceuticals such as ibuprofen, paracetamol, aspirin, oral contraceptives, drugs for the prevention of motion sickness and food supplements such as table vitamins and minerals have been studied for the purposes of retrospective dosimetry using optically stimulated luminescence (OSL...

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Autores principales: Ekendahl, Daniela, Reimitz, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243327/
https://www.ncbi.nlm.nih.gov/pubmed/35784234
http://dx.doi.org/10.3389/fpubh.2022.908016
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author Ekendahl, Daniela
Reimitz, Dan
author_facet Ekendahl, Daniela
Reimitz, Dan
author_sort Ekendahl, Daniela
collection PubMed
description Several common pharmaceuticals such as ibuprofen, paracetamol, aspirin, oral contraceptives, drugs for the prevention of motion sickness and food supplements such as table vitamins and minerals have been studied for the purposes of retrospective dosimetry using optically stimulated luminescence (OSL). The essence is that the tablets with these drug substances contain additive crystalline materials which, after irradiation and stimulation, may exhibit luminescence. For most of the pharmaceuticals and food supplements, a radiation-induced dose-dependent OSL signal was detected. Subsequently, basic dosimetric characteristics of the materials were studied, specifically sensitivity changes during repeated OSL readings, dose response, zero-dose, minimum detectable dose (MDD) and fading. The most radiation sensitive materials were food supplements with Mg providing zero-dose and MDD values at the level of several mGy. For Mg supplements, considerable sensitivity changes in OSL signal were observed. Despite this, they could be corrected using a Single-Aliquot Regenerative-dose (SAR) protocol. The OSL signals of the other materials were relatively weak but they were well reproducible and exhibited linear dose response. The MDD values were variable among the materials and ranged from 0.1 to several Gy. However, for some of the pharmaceuticals, a very high and variable zero-dose of more than 3 Gy was observed that would rule out the possibility of dose reconstruction for triage purposes. The OSL signal exhibited a significant fading rate for most of the materials. The measurements for dose reconstruction should be performed as soon as possible after irradiation, i.e. within a maximum of a few days.
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spelling pubmed-92433272022-07-01 Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements Ekendahl, Daniela Reimitz, Dan Front Public Health Public Health Several common pharmaceuticals such as ibuprofen, paracetamol, aspirin, oral contraceptives, drugs for the prevention of motion sickness and food supplements such as table vitamins and minerals have been studied for the purposes of retrospective dosimetry using optically stimulated luminescence (OSL). The essence is that the tablets with these drug substances contain additive crystalline materials which, after irradiation and stimulation, may exhibit luminescence. For most of the pharmaceuticals and food supplements, a radiation-induced dose-dependent OSL signal was detected. Subsequently, basic dosimetric characteristics of the materials were studied, specifically sensitivity changes during repeated OSL readings, dose response, zero-dose, minimum detectable dose (MDD) and fading. The most radiation sensitive materials were food supplements with Mg providing zero-dose and MDD values at the level of several mGy. For Mg supplements, considerable sensitivity changes in OSL signal were observed. Despite this, they could be corrected using a Single-Aliquot Regenerative-dose (SAR) protocol. The OSL signals of the other materials were relatively weak but they were well reproducible and exhibited linear dose response. The MDD values were variable among the materials and ranged from 0.1 to several Gy. However, for some of the pharmaceuticals, a very high and variable zero-dose of more than 3 Gy was observed that would rule out the possibility of dose reconstruction for triage purposes. The OSL signal exhibited a significant fading rate for most of the materials. The measurements for dose reconstruction should be performed as soon as possible after irradiation, i.e. within a maximum of a few days. Frontiers Media S.A. 2022-06-16 /pmc/articles/PMC9243327/ /pubmed/35784234 http://dx.doi.org/10.3389/fpubh.2022.908016 Text en Copyright © 2022 Ekendahl and Reimitz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Ekendahl, Daniela
Reimitz, Dan
Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements
title Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements
title_full Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements
title_fullStr Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements
title_full_unstemmed Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements
title_short Retrospective OSL Dosimetry With Common Pharmaceuticals and Food Supplements
title_sort retrospective osl dosimetry with common pharmaceuticals and food supplements
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243327/
https://www.ncbi.nlm.nih.gov/pubmed/35784234
http://dx.doi.org/10.3389/fpubh.2022.908016
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