Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells

The CRISPR/Cas9 system, originally derived from the prokaryotic adaptive immune system, has been developed as efficient genome editing tools. It enables precise gene manipulation on chromosomal DNA through the specific binding of programmable sgRNA to target DNA, and the Cas9 protein, which has endo...

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Detalles Bibliográficos
Autores principales: Tan, Renke, Du, Wenhao, Liu, Yiyang, Cong, Xiaoji, Bai, Meirong, Jiang, Chenxiao, Li, Zengxia, Tan, Minjia, Ma, Dengke K., Huang, Qiang, Jiang, Wei, Dang, Yongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243344/
https://www.ncbi.nlm.nih.gov/pubmed/35782966
http://dx.doi.org/10.1016/j.gendis.2020.09.003

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