PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation

PKAN disease is caused by mutations in the PANK2 gene, encoding the mitochondrial enzyme pantothenate kinase 2, catalyzing the first and key reaction in Coenzyme A (CoA) biosynthetic process. This disorder is characterized by progressive neurodegeneration and excessive iron deposition in the brain....

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Detalles Bibliográficos
Autores principales: Ripamonti, Maddalena, Santambrogio, Paolo, Racchetti, Gabriella, Cozzi, Anna, Di Meo, Ivano, Tiranti, Valeria, Levi, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243464/
https://www.ncbi.nlm.nih.gov/pubmed/35783094
http://dx.doi.org/10.3389/fncel.2022.878103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243464/
https://www.ncbi.nlm.nih.gov/pubmed/35783094
http://dx.doi.org/10.3389/fncel.2022.878103

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