Cargando…

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

Migraine represents one of the major causes of disability worldwide and is more prevalent in women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently reported trigger in migraine patients, but the underlying mechanisms are not fully understood. However, it is know...

Descripción completa

Detalles Bibliográficos
Autores principales: Viero, Fernanda Tibolla, Rodrigues, Patrícia, Frare, Julia Maria, Da Silva, Náthaly Andrighetto Ruviaro, Ferreira, Marcella de Amorim, Da Silva, Ana Merian, Pereira, Gabriele Cheiran, Ferreira, Juliano, Pillat, Micheli Mainardi, Bocchi, Guilherme Vargas, Nassini, Romina, Geppetti, Pierangelo, Trevisan, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243578/
https://www.ncbi.nlm.nih.gov/pubmed/35784726
http://dx.doi.org/10.3389/fphar.2022.911105
_version_ 1784738346346479616
author Viero, Fernanda Tibolla
Rodrigues, Patrícia
Frare, Julia Maria
Da Silva, Náthaly Andrighetto Ruviaro
Ferreira, Marcella de Amorim
Da Silva, Ana Merian
Pereira, Gabriele Cheiran
Ferreira, Juliano
Pillat, Micheli Mainardi
Bocchi, Guilherme Vargas
Nassini, Romina
Geppetti, Pierangelo
Trevisan, Gabriela
author_facet Viero, Fernanda Tibolla
Rodrigues, Patrícia
Frare, Julia Maria
Da Silva, Náthaly Andrighetto Ruviaro
Ferreira, Marcella de Amorim
Da Silva, Ana Merian
Pereira, Gabriele Cheiran
Ferreira, Juliano
Pillat, Micheli Mainardi
Bocchi, Guilherme Vargas
Nassini, Romina
Geppetti, Pierangelo
Trevisan, Gabriela
author_sort Viero, Fernanda Tibolla
collection PubMed
description Migraine represents one of the major causes of disability worldwide and is more prevalent in women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently reported trigger in migraine patients, but the underlying mechanisms are not fully understood. However, it is known that patients with migraine have higher levels of plasma inflammatory cytokines and calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable sound is already used as a model of painful sensitization, but migraine-like behaviors and sexual dimorphism have not yet been evaluated. This study characterized nociception and anxiety-related symptoms after the induction of sound stress in mice. C57BL/6 mice (20–30 g) were exposed to unpredictable sound stress for 3 days, nonconsecutive days. We observed enhanced plasma corticosterone levels on day 1 after stress induction. First, 7 days after the last stress session, mice developed hind paw and periorbital mechanical allodynia, grimacing pain behavior, anxiety-like symptoms, and reduced exploratory behavior. The nociceptive and behavioral alterations detected in this model were mostly shown in female stressed mice at day 7 post-stress. In addition, on day 7 post-stress nociception, these behaviors were consistently abolished by the CGRP receptor antagonist olcegepant (BIBN4096BS, 100 mg/kg by intraperitoneal route) in female and male stressed mice. We also demonstrated an increase in interleukine-6 (IL-6), tumor necrosis factor (TNF-α), and CGRP levels in stressed mice plasma, with female mice showing higher levels compared to male mice. This stress paradigm allows further preclinical investigation of mechanisms contributing to migraine-inducing pain.
format Online
Article
Text
id pubmed-9243578
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92435782022-07-01 Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism Viero, Fernanda Tibolla Rodrigues, Patrícia Frare, Julia Maria Da Silva, Náthaly Andrighetto Ruviaro Ferreira, Marcella de Amorim Da Silva, Ana Merian Pereira, Gabriele Cheiran Ferreira, Juliano Pillat, Micheli Mainardi Bocchi, Guilherme Vargas Nassini, Romina Geppetti, Pierangelo Trevisan, Gabriela Front Pharmacol Pharmacology Migraine represents one of the major causes of disability worldwide and is more prevalent in women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently reported trigger in migraine patients, but the underlying mechanisms are not fully understood. However, it is known that patients with migraine have higher levels of plasma inflammatory cytokines and calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable sound is already used as a model of painful sensitization, but migraine-like behaviors and sexual dimorphism have not yet been evaluated. This study characterized nociception and anxiety-related symptoms after the induction of sound stress in mice. C57BL/6 mice (20–30 g) were exposed to unpredictable sound stress for 3 days, nonconsecutive days. We observed enhanced plasma corticosterone levels on day 1 after stress induction. First, 7 days after the last stress session, mice developed hind paw and periorbital mechanical allodynia, grimacing pain behavior, anxiety-like symptoms, and reduced exploratory behavior. The nociceptive and behavioral alterations detected in this model were mostly shown in female stressed mice at day 7 post-stress. In addition, on day 7 post-stress nociception, these behaviors were consistently abolished by the CGRP receptor antagonist olcegepant (BIBN4096BS, 100 mg/kg by intraperitoneal route) in female and male stressed mice. We also demonstrated an increase in interleukine-6 (IL-6), tumor necrosis factor (TNF-α), and CGRP levels in stressed mice plasma, with female mice showing higher levels compared to male mice. This stress paradigm allows further preclinical investigation of mechanisms contributing to migraine-inducing pain. Frontiers Media S.A. 2022-06-16 /pmc/articles/PMC9243578/ /pubmed/35784726 http://dx.doi.org/10.3389/fphar.2022.911105 Text en Copyright © 2022 Viero, Rodrigues, Frare, Da Silva, Ferreira, Da Silva, Pereira, Ferreira, Pillat, Bocchi, Nassini, Geppetti and Trevisan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Viero, Fernanda Tibolla
Rodrigues, Patrícia
Frare, Julia Maria
Da Silva, Náthaly Andrighetto Ruviaro
Ferreira, Marcella de Amorim
Da Silva, Ana Merian
Pereira, Gabriele Cheiran
Ferreira, Juliano
Pillat, Micheli Mainardi
Bocchi, Guilherme Vargas
Nassini, Romina
Geppetti, Pierangelo
Trevisan, Gabriela
Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism
title Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism
title_full Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism
title_fullStr Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism
title_full_unstemmed Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism
title_short Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism
title_sort unpredictable sound stress model causes migraine-like behaviors in mice with sexual dimorphism
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243578/
https://www.ncbi.nlm.nih.gov/pubmed/35784726
http://dx.doi.org/10.3389/fphar.2022.911105
work_keys_str_mv AT vierofernandatibolla unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT rodriguespatricia unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT frarejuliamaria unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT dasilvanathalyandrighettoruviaro unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT ferreiramarcelladeamorim unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT dasilvaanamerian unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT pereiragabrielecheiran unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT ferreirajuliano unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT pillatmichelimainardi unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT bocchiguilhermevargas unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT nassiniromina unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT geppettipierangelo unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism
AT trevisangabriela unpredictablesoundstressmodelcausesmigrainelikebehaviorsinmicewithsexualdimorphism