A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge

• A replication-competent recombinant VSV with RABV-G protein replacement was generated. • Single dose of VSV-RABV(G) immunization induces potent anti-RABV(G) immune response, including viral neutralizing antibodies. • Mice intranasally immunized with single dose of VSV-RABV(G) were 100% protected u...

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Detalles Bibliográficos
Autores principales: Liang, Minglong, Wang, Zongmei, Wu, Chuanjian, Xiong, Sidong, Zhao, Ling, Dong, Chunsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243626/
https://www.ncbi.nlm.nih.gov/pubmed/35618603
http://dx.doi.org/10.1016/j.virs.2022.02.008
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author Liang, Minglong
Wang, Zongmei
Wu, Chuanjian
Xiong, Sidong
Zhao, Ling
Dong, Chunsheng
author_facet Liang, Minglong
Wang, Zongmei
Wu, Chuanjian
Xiong, Sidong
Zhao, Ling
Dong, Chunsheng
author_sort Liang, Minglong
collection PubMed
description • A replication-competent recombinant VSV with RABV-G protein replacement was generated. • Single dose of VSV-RABV(G) immunization induces potent anti-RABV(G) immune response, including viral neutralizing antibodies. • Mice intranasally immunized with single dose of VSV-RABV(G) were 100% protected upon RABV challenge.
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spelling pubmed-92436262022-07-01 A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge Liang, Minglong Wang, Zongmei Wu, Chuanjian Xiong, Sidong Zhao, Ling Dong, Chunsheng Virol Sin Letter • A replication-competent recombinant VSV with RABV-G protein replacement was generated. • Single dose of VSV-RABV(G) immunization induces potent anti-RABV(G) immune response, including viral neutralizing antibodies. • Mice intranasally immunized with single dose of VSV-RABV(G) were 100% protected upon RABV challenge. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-02-25 /pmc/articles/PMC9243626/ /pubmed/35618603 http://dx.doi.org/10.1016/j.virs.2022.02.008 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Liang, Minglong
Wang, Zongmei
Wu, Chuanjian
Xiong, Sidong
Zhao, Ling
Dong, Chunsheng
A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge
title A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge
title_full A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge
title_fullStr A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge
title_full_unstemmed A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge
title_short A single dose of recombinant VSV-RABV(G) vaccine provides full protection against RABV challenge
title_sort single dose of recombinant vsv-rabv(g) vaccine provides full protection against rabv challenge
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243626/
https://www.ncbi.nlm.nih.gov/pubmed/35618603
http://dx.doi.org/10.1016/j.virs.2022.02.008
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