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Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019

During 2018–2019, a severe human adenovirus (HAdV) infection outbreak occurred in southern China. Here, we screened 18 respiratory pathogens in 1704 children (≤ 14 years old) hospitalized with acute respiratory illness in Guangzhou, China, in 2019. In total, 151 patients had positive HAdV test resul...

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Autores principales: Liu, Wenkuan, Qiu, Shuyan, Zhang, Li, Wu, Hongkai, Tian, Xingui, Li, Xiao, Xu, Duo, Dai, Jing, Gu, Shujun, Liu, Qian, Chen, Dehui, Zhou, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243629/
https://www.ncbi.nlm.nih.gov/pubmed/35307598
http://dx.doi.org/10.1016/j.virs.2022.01.010
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author Liu, Wenkuan
Qiu, Shuyan
Zhang, Li
Wu, Hongkai
Tian, Xingui
Li, Xiao
Xu, Duo
Dai, Jing
Gu, Shujun
Liu, Qian
Chen, Dehui
Zhou, Rong
author_facet Liu, Wenkuan
Qiu, Shuyan
Zhang, Li
Wu, Hongkai
Tian, Xingui
Li, Xiao
Xu, Duo
Dai, Jing
Gu, Shujun
Liu, Qian
Chen, Dehui
Zhou, Rong
author_sort Liu, Wenkuan
collection PubMed
description During 2018–2019, a severe human adenovirus (HAdV) infection outbreak occurred in southern China. Here, we screened 18 respiratory pathogens in 1704 children (≤ 14 years old) hospitalized with acute respiratory illness in Guangzhou, China, in 2019. In total, 151 patients had positive HAdV test results; 34.4% (52/151) of them exhibited severe illness. HAdV infection occurred throughout the year, with a peak in summer. The median patient age was 3.0 (interquartile range: 1.1–5.0) years. Patients with severe HAdV infection exhibited increases in 12 clinical indexes (P ​≤ ​0.019) and decreases in four indexes (P ​≤ ​0.007), compared with patients exhibiting non-severe infection. No significant differences were found in age or sex distribution according to HAdV infection severity (P ​> ​0.05); however, the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity (P ​< ​0.05). The main epidemic types were HAdV-3 (47.0%, 71/151) and HAdV-7 (46.4%, 70/151). However, the severe illness rate was significantly higher in patients with HAdV-7 (51.4%) than in patients with HAdV-3 (19.7%) and other types of HAdV (20%) (P ​< ​0.001). Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates. A representative HAdV-7 isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01 (accession no. DQ099432) (P ​> ​0.05); the HAdV-7 isolate exhibited stronger virulence and infectivity, compared with HAdV-3 (P ​< ​0.001). Overall, comorbid disease, HAdV co-infection, and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection; these data can facilitate treatment, control, and prevention of HAdV infection.
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spelling pubmed-92436292022-07-01 Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019 Liu, Wenkuan Qiu, Shuyan Zhang, Li Wu, Hongkai Tian, Xingui Li, Xiao Xu, Duo Dai, Jing Gu, Shujun Liu, Qian Chen, Dehui Zhou, Rong Virol Sin Research Article During 2018–2019, a severe human adenovirus (HAdV) infection outbreak occurred in southern China. Here, we screened 18 respiratory pathogens in 1704 children (≤ 14 years old) hospitalized with acute respiratory illness in Guangzhou, China, in 2019. In total, 151 patients had positive HAdV test results; 34.4% (52/151) of them exhibited severe illness. HAdV infection occurred throughout the year, with a peak in summer. The median patient age was 3.0 (interquartile range: 1.1–5.0) years. Patients with severe HAdV infection exhibited increases in 12 clinical indexes (P ​≤ ​0.019) and decreases in four indexes (P ​≤ ​0.007), compared with patients exhibiting non-severe infection. No significant differences were found in age or sex distribution according to HAdV infection severity (P ​> ​0.05); however, the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity (P ​< ​0.05). The main epidemic types were HAdV-3 (47.0%, 71/151) and HAdV-7 (46.4%, 70/151). However, the severe illness rate was significantly higher in patients with HAdV-7 (51.4%) than in patients with HAdV-3 (19.7%) and other types of HAdV (20%) (P ​< ​0.001). Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates. A representative HAdV-7 isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01 (accession no. DQ099432) (P ​> ​0.05); the HAdV-7 isolate exhibited stronger virulence and infectivity, compared with HAdV-3 (P ​< ​0.001). Overall, comorbid disease, HAdV co-infection, and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection; these data can facilitate treatment, control, and prevention of HAdV infection. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-01-17 /pmc/articles/PMC9243629/ /pubmed/35307598 http://dx.doi.org/10.1016/j.virs.2022.01.010 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Liu, Wenkuan
Qiu, Shuyan
Zhang, Li
Wu, Hongkai
Tian, Xingui
Li, Xiao
Xu, Duo
Dai, Jing
Gu, Shujun
Liu, Qian
Chen, Dehui
Zhou, Rong
Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019
title Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019
title_full Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019
title_fullStr Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019
title_full_unstemmed Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019
title_short Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019
title_sort analysis of severe human adenovirus infection outbreak in guangdong province, southern china in 2019
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243629/
https://www.ncbi.nlm.nih.gov/pubmed/35307598
http://dx.doi.org/10.1016/j.virs.2022.01.010
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