Optimization and validation of CAR transduction into human primary NK cells using CRISPR and AAV

Human primary natural killer (NK) cells are being widely advanced for cancer immunotherapy. However, methods for gene editing of these cells have suffered low transduction rates, high cell death, and loss of transgene expression after expansion. Here, we developed a highly efficient method for site-...

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Detalles Bibliográficos
Autores principales: Naeimi Kararoudi, Meisam, Likhite, Shibi, Elmas, Ezgi, Yamamoto, Kenta, Schwartz, Maura, Sorathia, Kinnari, de Souza Fernandes Pereira, Marcelo, Sezgin, Yasemin, Devine, Raymond D., Lyberger, Justin M., Behbehani, Gregory K., Chakravarti, Nitin, Moriarity, Branden S., Meyer, Kathrin, Lee, Dean A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243630/
https://www.ncbi.nlm.nih.gov/pubmed/35784645
http://dx.doi.org/10.1016/j.crmeth.2022.100236

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