Overcoming the LAG3 phase problem

Lymphocyte activation gene 3 (LAG3) is an important checkpoint inhibitor molecule of immunotherapeutic interest. New crystal structures of LAG3 provide important insight into its molecular architecture, laying the groundwork for future basic and applied investigations.

Detalles Bibliográficos
Autores principales: Petersen, Jan, Rossjohn, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243723/
https://www.ncbi.nlm.nih.gov/pubmed/35761086
http://dx.doi.org/10.1038/s41590-022-01239-6
Descripción
Sumario:Lymphocyte activation gene 3 (LAG3) is an important checkpoint inhibitor molecule of immunotherapeutic interest. New crystal structures of LAG3 provide important insight into its molecular architecture, laying the groundwork for future basic and applied investigations.

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