Penicillin G concentrations required for prophylaxis against Group A Streptococcus infection evaluated using a hollow fibre model and mathematical modelling

BACKGROUND: Acute rheumatic fever (ARF), an autoimmune reaction to Group A Streptococcus (Streptococcus pyogenes; Strep A) infection, can cause rheumatic heart disease (RHD). New formulations of long-acting penicillins are being developed for secondary prophylaxis of ARF and RHD. OBJECTIVES: To eval...

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Detalles Bibliográficos
Autores principales: Tait, Jessica R, Barnett, Timothy C, Rogers, Kate E, Lee, Wee Leng, Page-Sharp, Madhu, Manning, Laurens, Boyd, Ben J, Carapetis, Jonathan R, Nation, Roger L, Landersdorfer, Cornelia B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244232/
https://www.ncbi.nlm.nih.gov/pubmed/35470370
http://dx.doi.org/10.1093/jac/dkac124

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