Cargando…

Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations

Mapping human behaviors to brain activity has become a key focus in modern cognitive neuroscience. As methods such as functional MRI (fMRI) advance cognitive scientists show an increasing interest in investigating neural activity in terms of functional connectivity and brain networks, rather than ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Mengting, Amey, Rachel C., Backer, Robert A., Simon, Julia P., Forbes, Chad E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244405/
https://www.ncbi.nlm.nih.gov/pubmed/35782044
http://dx.doi.org/10.3389/fnhum.2022.875201
_version_ 1784738517778169856
author Liu, Mengting
Amey, Rachel C.
Backer, Robert A.
Simon, Julia P.
Forbes, Chad E.
author_facet Liu, Mengting
Amey, Rachel C.
Backer, Robert A.
Simon, Julia P.
Forbes, Chad E.
author_sort Liu, Mengting
collection PubMed
description Mapping human behaviors to brain activity has become a key focus in modern cognitive neuroscience. As methods such as functional MRI (fMRI) advance cognitive scientists show an increasing interest in investigating neural activity in terms of functional connectivity and brain networks, rather than activation in a single brain region. Due to the noisy nature of neural activity, determining how behaviors are associated with specific neural signals is not well-established. Previous research has suggested graph theory techniques as a solution. Graph theory provides an opportunity to interpret human behaviors in terms of the topological organization of brain network architecture. Graph theory-based approaches, however, only scratch the surface of what neural connections relate to human behavior. Recently, the development of data-driven methods, e.g., machine learning and deep learning approaches, provide a new perspective to study the relationship between brain networks and human behaviors across the whole brain, expanding upon past literatures. In this review, we sought to revisit these data-driven approaches to facilitate our understanding of neural mechanisms and build models of human behaviors. We start with the popular graph theory approach and then discuss other data-driven approaches such as connectome-based predictive modeling, multivariate pattern analysis, network dynamic modeling, and deep learning techniques that quantify meaningful networks and connectivity related to cognition and behaviors. Importantly, for each topic, we discuss the pros and cons of the methods in addition to providing examples using our own data for each technique to describe how these methods can be applied to real-world neuroimaging data.
format Online
Article
Text
id pubmed-9244405
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92444052022-07-01 Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations Liu, Mengting Amey, Rachel C. Backer, Robert A. Simon, Julia P. Forbes, Chad E. Front Hum Neurosci Human Neuroscience Mapping human behaviors to brain activity has become a key focus in modern cognitive neuroscience. As methods such as functional MRI (fMRI) advance cognitive scientists show an increasing interest in investigating neural activity in terms of functional connectivity and brain networks, rather than activation in a single brain region. Due to the noisy nature of neural activity, determining how behaviors are associated with specific neural signals is not well-established. Previous research has suggested graph theory techniques as a solution. Graph theory provides an opportunity to interpret human behaviors in terms of the topological organization of brain network architecture. Graph theory-based approaches, however, only scratch the surface of what neural connections relate to human behavior. Recently, the development of data-driven methods, e.g., machine learning and deep learning approaches, provide a new perspective to study the relationship between brain networks and human behaviors across the whole brain, expanding upon past literatures. In this review, we sought to revisit these data-driven approaches to facilitate our understanding of neural mechanisms and build models of human behaviors. We start with the popular graph theory approach and then discuss other data-driven approaches such as connectome-based predictive modeling, multivariate pattern analysis, network dynamic modeling, and deep learning techniques that quantify meaningful networks and connectivity related to cognition and behaviors. Importantly, for each topic, we discuss the pros and cons of the methods in addition to providing examples using our own data for each technique to describe how these methods can be applied to real-world neuroimaging data. Frontiers Media S.A. 2022-06-16 /pmc/articles/PMC9244405/ /pubmed/35782044 http://dx.doi.org/10.3389/fnhum.2022.875201 Text en Copyright © 2022 Liu, Amey, Backer, Simon and Forbes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Liu, Mengting
Amey, Rachel C.
Backer, Robert A.
Simon, Julia P.
Forbes, Chad E.
Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations
title Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations
title_full Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations
title_fullStr Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations
title_full_unstemmed Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations
title_short Behavioral Studies Using Large-Scale Brain Networks – Methods and Validations
title_sort behavioral studies using large-scale brain networks – methods and validations
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244405/
https://www.ncbi.nlm.nih.gov/pubmed/35782044
http://dx.doi.org/10.3389/fnhum.2022.875201
work_keys_str_mv AT liumengting behavioralstudiesusinglargescalebrainnetworksmethodsandvalidations
AT ameyrachelc behavioralstudiesusinglargescalebrainnetworksmethodsandvalidations
AT backerroberta behavioralstudiesusinglargescalebrainnetworksmethodsandvalidations
AT simonjuliap behavioralstudiesusinglargescalebrainnetworksmethodsandvalidations
AT forbeschade behavioralstudiesusinglargescalebrainnetworksmethodsandvalidations