Cargando…

Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)

PURPOSE: The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes. PARTICIPANTS: Established in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalk, Emma, Heekes, Alexa, Slogrove, Amy L, Phelanyane, Florence, Davies, Mary-Ann, Myer, Landon, Euvrard, Jonathan, Kroon, Max, Petro, Greg, Fieggen, Karen, Stewart, Chantal, Rhoda, Natasha, Gebhardt, Stefan, Osman, Ayesha, Anderson, Kim, Boulle, Andrew, Mehta, Ushma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244673/
https://www.ncbi.nlm.nih.gov/pubmed/35768089
http://dx.doi.org/10.1136/bmjopen-2021-060205
_version_ 1784738579889520640
author Kalk, Emma
Heekes, Alexa
Slogrove, Amy L
Phelanyane, Florence
Davies, Mary-Ann
Myer, Landon
Euvrard, Jonathan
Kroon, Max
Petro, Greg
Fieggen, Karen
Stewart, Chantal
Rhoda, Natasha
Gebhardt, Stefan
Osman, Ayesha
Anderson, Kim
Boulle, Andrew
Mehta, Ushma
author_facet Kalk, Emma
Heekes, Alexa
Slogrove, Amy L
Phelanyane, Florence
Davies, Mary-Ann
Myer, Landon
Euvrard, Jonathan
Kroon, Max
Petro, Greg
Fieggen, Karen
Stewart, Chantal
Rhoda, Natasha
Gebhardt, Stefan
Osman, Ayesha
Anderson, Kim
Boulle, Andrew
Mehta, Ushma
author_sort Kalk, Emma
collection PubMed
description PURPOSE: The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes. PARTICIPANTS: Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set. FINDINGS TO DATE: Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System. FUTURE PLANS: This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting.
format Online
Article
Text
id pubmed-9244673
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-92446732022-07-14 Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER) Kalk, Emma Heekes, Alexa Slogrove, Amy L Phelanyane, Florence Davies, Mary-Ann Myer, Landon Euvrard, Jonathan Kroon, Max Petro, Greg Fieggen, Karen Stewart, Chantal Rhoda, Natasha Gebhardt, Stefan Osman, Ayesha Anderson, Kim Boulle, Andrew Mehta, Ushma BMJ Open Public Health PURPOSE: The Western Cape Pregnancy Exposure Registry (PER) was established at two public sector healthcare sentinel sites in the Western Cape province, South Africa, to provide ongoing surveillance of drug exposures in pregnancy and associations with pregnancy outcomes. PARTICIPANTS: Established in 2016, all women attending their first antenatal visit at primary care obstetric facilities were enrolled and followed to pregnancy outcome regardless of the site (ie, primary, secondary, tertiary facility). Routine operational obstetric and medical data are digitised from the clinical stationery at the healthcare facilities. Data collection has been integrated into existing services and information platforms and supports routine operations. The PER is situated within the Provincial Health Data Centre, an information exchange that harmonises and consolidates all health-related electronic data in the province. Data are contributed via linkage across a unique identifier. This relationship limits the missing data in the PER, allows validation and avoids misclassification in the population-level data set. FINDINGS TO DATE: Approximately 5000 and 3500 pregnant women enter the data set annually at the urban and rural sites, respectively. As of August 2021, >30 000 pregnancies have been recorded and outcomes have been determined for 93%. Analysis of key obstetric and neonatal health indicators derived from the PER are consistent with the aggregate data in the District Health Information System. FUTURE PLANS: This represents significant infrastructure, able to address clinical and epidemiological concerns in a low/middle-income setting. BMJ Publishing Group 2022-06-29 /pmc/articles/PMC9244673/ /pubmed/35768089 http://dx.doi.org/10.1136/bmjopen-2021-060205 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Public Health
Kalk, Emma
Heekes, Alexa
Slogrove, Amy L
Phelanyane, Florence
Davies, Mary-Ann
Myer, Landon
Euvrard, Jonathan
Kroon, Max
Petro, Greg
Fieggen, Karen
Stewart, Chantal
Rhoda, Natasha
Gebhardt, Stefan
Osman, Ayesha
Anderson, Kim
Boulle, Andrew
Mehta, Ushma
Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
title Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
title_full Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
title_fullStr Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
title_full_unstemmed Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
title_short Cohort profile: the Western Cape Pregnancy Exposure Registry (WCPER)
title_sort cohort profile: the western cape pregnancy exposure registry (wcper)
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244673/
https://www.ncbi.nlm.nih.gov/pubmed/35768089
http://dx.doi.org/10.1136/bmjopen-2021-060205
work_keys_str_mv AT kalkemma cohortprofilethewesterncapepregnancyexposureregistrywcper
AT heekesalexa cohortprofilethewesterncapepregnancyexposureregistrywcper
AT slogroveamyl cohortprofilethewesterncapepregnancyexposureregistrywcper
AT phelanyaneflorence cohortprofilethewesterncapepregnancyexposureregistrywcper
AT daviesmaryann cohortprofilethewesterncapepregnancyexposureregistrywcper
AT myerlandon cohortprofilethewesterncapepregnancyexposureregistrywcper
AT euvrardjonathan cohortprofilethewesterncapepregnancyexposureregistrywcper
AT kroonmax cohortprofilethewesterncapepregnancyexposureregistrywcper
AT petrogreg cohortprofilethewesterncapepregnancyexposureregistrywcper
AT fieggenkaren cohortprofilethewesterncapepregnancyexposureregistrywcper
AT stewartchantal cohortprofilethewesterncapepregnancyexposureregistrywcper
AT rhodanatasha cohortprofilethewesterncapepregnancyexposureregistrywcper
AT gebhardtstefan cohortprofilethewesterncapepregnancyexposureregistrywcper
AT osmanayesha cohortprofilethewesterncapepregnancyexposureregistrywcper
AT andersonkim cohortprofilethewesterncapepregnancyexposureregistrywcper
AT boulleandrew cohortprofilethewesterncapepregnancyexposureregistrywcper
AT mehtaushma cohortprofilethewesterncapepregnancyexposureregistrywcper