Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D(1) Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms

Low doses of dopamine D(1) agonists improve working memory-related behavior, but high doses eliminate the improvement, thus yielding an ‘inverted-U’ dose-response curve. This dose-dependency also occurs at the single neuron level in the prefrontal cortex where the cellular basis of working memory is...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Kocher, Susan D., Lewis, Mechelle M., Mailman, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244699/
https://www.ncbi.nlm.nih.gov/pubmed/35784852
http://dx.doi.org/10.3389/fnins.2022.898051

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