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Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders
Upon embryo implantation, the uterine mucosa - the endometrium - transforms into a robust decidual matrix that accommodates the fetal placenta throughout pregnancy. This transition is driven by the differentiation of endometrial fibroblasts into specialised decidual cells. A synchronised influx of c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244729/ https://www.ncbi.nlm.nih.gov/pubmed/35779492 http://dx.doi.org/10.1016/j.ebiom.2022.104134 |
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author | Bortoletto, Pietro Lucas, Emma S. Melo, Pedro Gallos, Ioannis D. Devall, Adam J. Bourne, Tom Quenby, Siobhan Bennett, Phillip R. Coomarasamy, Arri Brosens, Jan J. |
author_facet | Bortoletto, Pietro Lucas, Emma S. Melo, Pedro Gallos, Ioannis D. Devall, Adam J. Bourne, Tom Quenby, Siobhan Bennett, Phillip R. Coomarasamy, Arri Brosens, Jan J. |
author_sort | Bortoletto, Pietro |
collection | PubMed |
description | Upon embryo implantation, the uterine mucosa - the endometrium - transforms into a robust decidual matrix that accommodates the fetal placenta throughout pregnancy. This transition is driven by the differentiation of endometrial fibroblasts into specialised decidual cells. A synchronised influx of circulating natural killer (NK) cells and bone marrow-derived mesenchymal stem/progenitor cells (BM-MSC) is pivotal for decidual homeostasis and expansion in early pregnancy. We hypothesise that pathological signals interfering with the recruitment or activity of extrauterine cells at the maternal-fetal interface link miscarriage to subsequent adverse pregnancy outcomes, including further pregnancy losses and preterm labour. NK cells and BM-MSC are key homeostatic regulators in multiple tissues, pointing towards a shared aetiology between recurrent miscarriage and age-related disorders, including cardiometabolic disease. We propose the term ‘miscarriage syndrome’ to capture the health risks associated with miscarriage and discuss how this paradigm can inform clinical practice and accelerate the development of preventative strategies. |
format | Online Article Text |
id | pubmed-9244729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92447292022-07-01 Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders Bortoletto, Pietro Lucas, Emma S. Melo, Pedro Gallos, Ioannis D. Devall, Adam J. Bourne, Tom Quenby, Siobhan Bennett, Phillip R. Coomarasamy, Arri Brosens, Jan J. eBioMedicine Personal View Upon embryo implantation, the uterine mucosa - the endometrium - transforms into a robust decidual matrix that accommodates the fetal placenta throughout pregnancy. This transition is driven by the differentiation of endometrial fibroblasts into specialised decidual cells. A synchronised influx of circulating natural killer (NK) cells and bone marrow-derived mesenchymal stem/progenitor cells (BM-MSC) is pivotal for decidual homeostasis and expansion in early pregnancy. We hypothesise that pathological signals interfering with the recruitment or activity of extrauterine cells at the maternal-fetal interface link miscarriage to subsequent adverse pregnancy outcomes, including further pregnancy losses and preterm labour. NK cells and BM-MSC are key homeostatic regulators in multiple tissues, pointing towards a shared aetiology between recurrent miscarriage and age-related disorders, including cardiometabolic disease. We propose the term ‘miscarriage syndrome’ to capture the health risks associated with miscarriage and discuss how this paradigm can inform clinical practice and accelerate the development of preventative strategies. Elsevier 2022-06-29 /pmc/articles/PMC9244729/ /pubmed/35779492 http://dx.doi.org/10.1016/j.ebiom.2022.104134 Text en © 2022 Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Personal View Bortoletto, Pietro Lucas, Emma S. Melo, Pedro Gallos, Ioannis D. Devall, Adam J. Bourne, Tom Quenby, Siobhan Bennett, Phillip R. Coomarasamy, Arri Brosens, Jan J. Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders |
title | Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders |
title_full | Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders |
title_fullStr | Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders |
title_full_unstemmed | Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders |
title_short | Miscarriage syndrome: Linking early pregnancy loss to obstetric and age-related disorders |
title_sort | miscarriage syndrome: linking early pregnancy loss to obstetric and age-related disorders |
topic | Personal View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244729/ https://www.ncbi.nlm.nih.gov/pubmed/35779492 http://dx.doi.org/10.1016/j.ebiom.2022.104134 |
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