Platelet dysfunction in platelet-type von Willebrand disease due to the constitutive triggering of the Lyn-PECAM1 inhibitory pathway

Platelet-type von Willebrand disease (PT-VWD) is an inherited platelet disorder. It is characterized by macrothrombocytopenia and mucocutaneous bleeding, of variable severity, due to gain-of-function variants of GP1BA conferring to glycoprotein Ibα (GPIbα) enhanced affinity for von Willebrand factor...

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Detalles Bibliográficos
Autores principales: Bury, Loredana, Falcinelli, Emanuela, Mezzasoma, Anna Maria, Guglielmini, Giuseppe, Momi, Stefania, Gresele, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article - Platelet Biology and its Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244828/
https://www.ncbi.nlm.nih.gov/pubmed/34407603
http://dx.doi.org/10.3324/haematol.2021.278776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244828/
https://www.ncbi.nlm.nih.gov/pubmed/34407603
http://dx.doi.org/10.3324/haematol.2021.278776

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