Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-bind...

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Detalles Bibliográficos
Autores principales: Coverdale, James P. C., van den Berg, Hugo A., Khazaipoul, Siavash, Bridgewater, Hannah E., Stewart, Alan J., Blindauer, Claudia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244874/
https://www.ncbi.nlm.nih.gov/pubmed/35695483
http://dx.doi.org/10.1039/d2cc02278h
Descripción
Sumario:The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.

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