Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-bind...

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Detalles Bibliográficos
Autores principales: Coverdale, James P. C., van den Berg, Hugo A., Khazaipoul, Siavash, Bridgewater, Hannah E., Stewart, Alan J., Blindauer, Claudia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244874/
https://www.ncbi.nlm.nih.gov/pubmed/35695483
http://dx.doi.org/10.1039/d2cc02278h
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author Coverdale, James P. C.
van den Berg, Hugo A.
Khazaipoul, Siavash
Bridgewater, Hannah E.
Stewart, Alan J.
Blindauer, Claudia A.
author_facet Coverdale, James P. C.
van den Berg, Hugo A.
Khazaipoul, Siavash
Bridgewater, Hannah E.
Stewart, Alan J.
Blindauer, Claudia A.
author_sort Coverdale, James P. C.
collection PubMed
description The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
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spelling pubmed-92448742022-07-22 Albumin-mediated extracellular zinc speciation drives cellular zinc uptake Coverdale, James P. C. van den Berg, Hugo A. Khazaipoul, Siavash Bridgewater, Hannah E. Stewart, Alan J. Blindauer, Claudia A. Chem Commun (Camb) Chemistry The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux. The Royal Society of Chemistry 2022-06-02 /pmc/articles/PMC9244874/ /pubmed/35695483 http://dx.doi.org/10.1039/d2cc02278h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Coverdale, James P. C.
van den Berg, Hugo A.
Khazaipoul, Siavash
Bridgewater, Hannah E.
Stewart, Alan J.
Blindauer, Claudia A.
Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
title Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
title_full Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
title_fullStr Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
title_full_unstemmed Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
title_short Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
title_sort albumin-mediated extracellular zinc speciation drives cellular zinc uptake
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244874/
https://www.ncbi.nlm.nih.gov/pubmed/35695483
http://dx.doi.org/10.1039/d2cc02278h
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