Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts

The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type, cancer-associated fibroblasts (CAFs) with phospho...

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Detalles Bibliográficos
Autores principales: Sharpe, Benjamin P., Hayden, Annette, Manousopoulou, Antigoni, Cowie, Andrew, Walker, Robert C., Harrington, Jack, Izadi, Fereshteh, Breininger, Stella P., Gibson, Jane, Pickering, Oliver, Jaynes, Eleanor, Kyle, Ewan, Saunders, John H., Parsons, Simon L., Ritchie, Alison A., Clarke, Philip A., Collier, Pamela, Mongan, Nigel P., Bates, David O., Yacqub-Usman, Kiren, Garbis, Spiros D., Walters, Zoë, Rose-Zerilli, Matthew, Grabowska, Anna M., Underwood, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244979/
https://www.ncbi.nlm.nih.gov/pubmed/35732148
http://dx.doi.org/10.1016/j.xcrm.2022.100541

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