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Hypoxanthine is a pharmacodynamic marker of ischemic brain edema modified by glibenclamide
Brain edema after a large stroke causes significant morbidity and mortality. Here, we seek to identify pharmacodynamic markers of edema that are modified by intravenous (i.v.) glibenclamide (glyburide; BIIB093) treatment. Using metabolomic profiling of 399 plasma samples from patients enrolled in th...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9244997/ https://www.ncbi.nlm.nih.gov/pubmed/35700741 http://dx.doi.org/10.1016/j.xcrm.2022.100654 |