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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation, diminishing adaptive CD8(+) T cell antitumor activity. Although innate natural killer (NK) cells are triggered by loss of MHC class I, their response is often inadequate. To increase tumor susceptibility to both...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245005/ https://www.ncbi.nlm.nih.gov/pubmed/35688159 http://dx.doi.org/10.1016/j.xcrm.2022.100655 |