RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation, diminishing adaptive CD8(+) T cell antitumor activity. Although innate natural killer (NK) cells are triggered by loss of MHC class I, their response is often inadequate. To increase tumor susceptibility to both...

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Detalles Bibliográficos
Autores principales: Zhang, Zhengkui, Kong, Xiangjun, Ligtenberg, Maarten A., van Hal-van Veen, Susan E., Visser, Nils L., de Bruijn, Beaunelle, Stecker, Kelly, van der Helm, Pim W., Kuilman, Thomas, Hoefsmit, Esmée P., Vredevoogd, David W., Apriamashvili, Georgi, Baars, Beau, Voest, Emile E., Klarenbeek, Sjoerd, Altelaar, Maarten, Peeper, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245005/
https://www.ncbi.nlm.nih.gov/pubmed/35688159
http://dx.doi.org/10.1016/j.xcrm.2022.100655

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