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GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245048/ https://www.ncbi.nlm.nih.gov/pubmed/35783228 http://dx.doi.org/10.3389/fnbeh.2022.802530 |
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author | Gilfarb, Rachel A. Leuner, Benedetta |
author_facet | Gilfarb, Rachel A. Leuner, Benedetta |
author_sort | Gilfarb, Rachel A. |
collection | PubMed |
description | The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review summarizes current understanding of alterations that occur within the GABA system during the major hormonal transition periods of puberty, the ovarian cycle, pregnancy and the postpartum period, as well as reproductive aging. The functional impacts of altered inhibitory activity during these times are also discussed. Lastly, avenues for future research are identified, which, if pursued, can broaden understanding of the GABA system in the female brain and potentially lead to better treatments for women experiencing changes in brain function at each of these hormonal transition periods. |
format | Online Article Text |
id | pubmed-9245048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92450482022-07-01 GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan Gilfarb, Rachel A. Leuner, Benedetta Front Behav Neurosci Neuroscience The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review summarizes current understanding of alterations that occur within the GABA system during the major hormonal transition periods of puberty, the ovarian cycle, pregnancy and the postpartum period, as well as reproductive aging. The functional impacts of altered inhibitory activity during these times are also discussed. Lastly, avenues for future research are identified, which, if pursued, can broaden understanding of the GABA system in the female brain and potentially lead to better treatments for women experiencing changes in brain function at each of these hormonal transition periods. Frontiers Media S.A. 2022-06-16 /pmc/articles/PMC9245048/ /pubmed/35783228 http://dx.doi.org/10.3389/fnbeh.2022.802530 Text en Copyright © 2022 Gilfarb and Leuner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Gilfarb, Rachel A. Leuner, Benedetta GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan |
title | GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan |
title_full | GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan |
title_fullStr | GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan |
title_full_unstemmed | GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan |
title_short | GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan |
title_sort | gaba system modifications during periods of hormonal flux across the female lifespan |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245048/ https://www.ncbi.nlm.nih.gov/pubmed/35783228 http://dx.doi.org/10.3389/fnbeh.2022.802530 |
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