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GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan

The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review...

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Detalles Bibliográficos
Autores principales: Gilfarb, Rachel A., Leuner, Benedetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245048/
https://www.ncbi.nlm.nih.gov/pubmed/35783228
http://dx.doi.org/10.3389/fnbeh.2022.802530
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author Gilfarb, Rachel A.
Leuner, Benedetta
author_facet Gilfarb, Rachel A.
Leuner, Benedetta
author_sort Gilfarb, Rachel A.
collection PubMed
description The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review summarizes current understanding of alterations that occur within the GABA system during the major hormonal transition periods of puberty, the ovarian cycle, pregnancy and the postpartum period, as well as reproductive aging. The functional impacts of altered inhibitory activity during these times are also discussed. Lastly, avenues for future research are identified, which, if pursued, can broaden understanding of the GABA system in the female brain and potentially lead to better treatments for women experiencing changes in brain function at each of these hormonal transition periods.
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spelling pubmed-92450482022-07-01 GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan Gilfarb, Rachel A. Leuner, Benedetta Front Behav Neurosci Neuroscience The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite allopregnanolone, are among the most significant and have been shown to have widespread effects on the brain. This review summarizes current understanding of alterations that occur within the GABA system during the major hormonal transition periods of puberty, the ovarian cycle, pregnancy and the postpartum period, as well as reproductive aging. The functional impacts of altered inhibitory activity during these times are also discussed. Lastly, avenues for future research are identified, which, if pursued, can broaden understanding of the GABA system in the female brain and potentially lead to better treatments for women experiencing changes in brain function at each of these hormonal transition periods. Frontiers Media S.A. 2022-06-16 /pmc/articles/PMC9245048/ /pubmed/35783228 http://dx.doi.org/10.3389/fnbeh.2022.802530 Text en Copyright © 2022 Gilfarb and Leuner. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gilfarb, Rachel A.
Leuner, Benedetta
GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
title GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
title_full GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
title_fullStr GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
title_full_unstemmed GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
title_short GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan
title_sort gaba system modifications during periods of hormonal flux across the female lifespan
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245048/
https://www.ncbi.nlm.nih.gov/pubmed/35783228
http://dx.doi.org/10.3389/fnbeh.2022.802530
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