Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer

Gastrointestinal cancer represents a public health concern that seriously endangers human health. The emerging single-cell sequencing (SCS) technologies are different from the large-scale sequencing technologies which provide inaccurate data. SCS is a powerful tool for deciphering the single-cell re...

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Autores principales: Xie, Zhenliang, Li, Jincheng, Huang, Pu, Zhang, Ye, Yang, Jingkuan, Liu, Kangdong, Jiang, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245065/
https://www.ncbi.nlm.nih.gov/pubmed/35785171
http://dx.doi.org/10.3389/fonc.2022.905571
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author Xie, Zhenliang
Li, Jincheng
Huang, Pu
Zhang, Ye
Yang, Jingkuan
Liu, Kangdong
Jiang, Yanan
author_facet Xie, Zhenliang
Li, Jincheng
Huang, Pu
Zhang, Ye
Yang, Jingkuan
Liu, Kangdong
Jiang, Yanan
author_sort Xie, Zhenliang
collection PubMed
description Gastrointestinal cancer represents a public health concern that seriously endangers human health. The emerging single-cell sequencing (SCS) technologies are different from the large-scale sequencing technologies which provide inaccurate data. SCS is a powerful tool for deciphering the single-cell resolutions of cellular and molecular landscapes, revealing the features of single-cell genomes, transcriptomes, and epigenomes. Recently, SCS has been applied in the field of gastrointestinal cancer research for clarifying the origin and heterogeneity of gastrointestinal cancer, acquiring micro-environmental information, and improving diagnostic and treatment methods. This review outlines the applications of SCS in gastrointestinal cancer research and summarizes the most recent advances in the field.
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spelling pubmed-92450652022-07-01 Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer Xie, Zhenliang Li, Jincheng Huang, Pu Zhang, Ye Yang, Jingkuan Liu, Kangdong Jiang, Yanan Front Oncol Oncology Gastrointestinal cancer represents a public health concern that seriously endangers human health. The emerging single-cell sequencing (SCS) technologies are different from the large-scale sequencing technologies which provide inaccurate data. SCS is a powerful tool for deciphering the single-cell resolutions of cellular and molecular landscapes, revealing the features of single-cell genomes, transcriptomes, and epigenomes. Recently, SCS has been applied in the field of gastrointestinal cancer research for clarifying the origin and heterogeneity of gastrointestinal cancer, acquiring micro-environmental information, and improving diagnostic and treatment methods. This review outlines the applications of SCS in gastrointestinal cancer research and summarizes the most recent advances in the field. Frontiers Media S.A. 2022-06-16 /pmc/articles/PMC9245065/ /pubmed/35785171 http://dx.doi.org/10.3389/fonc.2022.905571 Text en Copyright © 2022 Xie, Li, Huang, Zhang, Yang, Liu and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xie, Zhenliang
Li, Jincheng
Huang, Pu
Zhang, Ye
Yang, Jingkuan
Liu, Kangdong
Jiang, Yanan
Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer
title Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer
title_full Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer
title_fullStr Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer
title_full_unstemmed Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer
title_short Applications and Achievements of Single-Cell Sequencing in Gastrointestinal Cancer
title_sort applications and achievements of single-cell sequencing in gastrointestinal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245065/
https://www.ncbi.nlm.nih.gov/pubmed/35785171
http://dx.doi.org/10.3389/fonc.2022.905571
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