Dual STAT-3 and IL-6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL-6/IL-6R/STAT-3 axis

Prostate cancer (PCa) is a key public health problem worldwide; at diagnosis, a high percentage of patients exhibit tumor cell invasion of adjacent tissue. STAT-3, IL-6 receptor (R) and IL-6 serum levels are associated with enhanced PCa migratory, invasive, clonogenic and metastatic ability. Inhibit...

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Detalles Bibliográficos
Autores principales: Méndez-Clemente, Anibal, Bravo-Cuellar, Alejandro, González-Ochoa, Salvador, Santiago-Mercado, Maria, Palafox-Mariscal, Luis, Jave-Suárez, Luis, Solorzano-Ibarra, Fabiola, Villaseñor-García, Maria, Ortiz-Lazareno, Pablo, Hernández-Flores, Georgina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245073/
https://www.ncbi.nlm.nih.gov/pubmed/35703345
http://dx.doi.org/10.3892/or.2022.8349

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