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Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women
OBJECTIVE: To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. METHODS: A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected using a s...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245172/ https://www.ncbi.nlm.nih.gov/pubmed/35783115 http://dx.doi.org/10.1002/agm2.12207 |
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author | Li, Shuang Wang, Yi He, Jieyu Huang, Wu Liao, Eryuan Liu, Youshuo Zhan, Junkun Wang, Yanjiao |
author_facet | Li, Shuang Wang, Yi He, Jieyu Huang, Wu Liao, Eryuan Liu, Youshuo Zhan, Junkun Wang, Yanjiao |
author_sort | Li, Shuang |
collection | PubMed |
description | OBJECTIVE: To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. METHODS: A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected using a standardized questionnaire. Measures of body composition were obtained using dual X‐ray absorptiometry. Body lean mass and fat mass indices were calculated by dividing total body lean/fat weight (kg) by body height squared (kg/m(2)). Blood samples were collected to assess liver and renal functions and lipid profiles. Analysis of variance, Pearson correlations, and multiple regression were used to analyze the associations between serum ALT and body composition. RESULTS: We found negative relationships of serum ALT with age, menopause duration, and serum HDL‐C levels. Serum ALT was positively correlated with BMI, serum TG levels, and the lean mass index and fat mass index. In a multivariate model adjusted for age, menopause duration, serum TG, and HDL‐C levels, a 1‐unit increase in the fat mass index was associated with a 0.176 U/L increase in ALT (95% CI 0.020 to 0.050, P < 0.001). CONCLUSION: Serum ALT was positively associated with the body fat mass index of postmenopausal women in China. |
format | Online Article Text |
id | pubmed-9245172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92451722022-07-01 Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women Li, Shuang Wang, Yi He, Jieyu Huang, Wu Liao, Eryuan Liu, Youshuo Zhan, Junkun Wang, Yanjiao Aging Med (Milton) Original Articles OBJECTIVE: To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. METHODS: A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected using a standardized questionnaire. Measures of body composition were obtained using dual X‐ray absorptiometry. Body lean mass and fat mass indices were calculated by dividing total body lean/fat weight (kg) by body height squared (kg/m(2)). Blood samples were collected to assess liver and renal functions and lipid profiles. Analysis of variance, Pearson correlations, and multiple regression were used to analyze the associations between serum ALT and body composition. RESULTS: We found negative relationships of serum ALT with age, menopause duration, and serum HDL‐C levels. Serum ALT was positively correlated with BMI, serum TG levels, and the lean mass index and fat mass index. In a multivariate model adjusted for age, menopause duration, serum TG, and HDL‐C levels, a 1‐unit increase in the fat mass index was associated with a 0.176 U/L increase in ALT (95% CI 0.020 to 0.050, P < 0.001). CONCLUSION: Serum ALT was positively associated with the body fat mass index of postmenopausal women in China. John Wiley and Sons Inc. 2022-05-24 /pmc/articles/PMC9245172/ /pubmed/35783115 http://dx.doi.org/10.1002/agm2.12207 Text en © 2022 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Li, Shuang Wang, Yi He, Jieyu Huang, Wu Liao, Eryuan Liu, Youshuo Zhan, Junkun Wang, Yanjiao Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
title | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
title_full | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
title_fullStr | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
title_full_unstemmed | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
title_short | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
title_sort | analysis of the relationship between serum alanine aminotransferase and body composition in chinese women |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245172/ https://www.ncbi.nlm.nih.gov/pubmed/35783115 http://dx.doi.org/10.1002/agm2.12207 |
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