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Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age

As humans age multiple forms of biological decay ensue, and many aspects of human biology can be measured to determine how far biological machinery has drifted from homeostasis. Research has led to aging clocks being developed that claim to predict biological age as opposed to chronological age. Agi...

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Autor principal: Palmer, Raymond D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245174/
https://www.ncbi.nlm.nih.gov/pubmed/35783114
http://dx.doi.org/10.1002/agm2.12197
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author Palmer, Raymond D.
author_facet Palmer, Raymond D.
author_sort Palmer, Raymond D.
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description As humans age multiple forms of biological decay ensue, and many aspects of human biology can be measured to determine how far biological machinery has drifted from homeostasis. Research has led to aging clocks being developed that claim to predict biological age as opposed to chronological age. Aging could be regarded as a measured loss of homeostatic biological equilibrium that augments biological decay in fully developed tissues. Measuring aspects of how far various elements of biology have drifted from a youthful state may allow us to make determinations on a subject's health but also make informed predictions on their biological age. As we see across human physiology, many facets that maintain human health taper off such as nicotinamide adenine dinucleotide, glutathione, catalase, super oxide dismutase, and more. Extracellular vesicle density also tapers off during age combined with epigenetic drift, telomere attrition, and stem cell exhaustion, whilst genomic instability and biological insults from environment and lifestyle factors increase. Measuring these types of biomarkers with aging clocks may allow subjects to understand their own health more accurately and enable subjects to better focus on their efforts in the pursuit of longevity and, in addition, allow healthcare practitioners to deliver better health advice.
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spelling pubmed-92451742022-07-01 Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age Palmer, Raymond D. Aging Med (Milton) Review Articles As humans age multiple forms of biological decay ensue, and many aspects of human biology can be measured to determine how far biological machinery has drifted from homeostasis. Research has led to aging clocks being developed that claim to predict biological age as opposed to chronological age. Aging could be regarded as a measured loss of homeostatic biological equilibrium that augments biological decay in fully developed tissues. Measuring aspects of how far various elements of biology have drifted from a youthful state may allow us to make determinations on a subject's health but also make informed predictions on their biological age. As we see across human physiology, many facets that maintain human health taper off such as nicotinamide adenine dinucleotide, glutathione, catalase, super oxide dismutase, and more. Extracellular vesicle density also tapers off during age combined with epigenetic drift, telomere attrition, and stem cell exhaustion, whilst genomic instability and biological insults from environment and lifestyle factors increase. Measuring these types of biomarkers with aging clocks may allow subjects to understand their own health more accurately and enable subjects to better focus on their efforts in the pursuit of longevity and, in addition, allow healthcare practitioners to deliver better health advice. John Wiley and Sons Inc. 2022-02-05 /pmc/articles/PMC9245174/ /pubmed/35783114 http://dx.doi.org/10.1002/agm2.12197 Text en © 2022 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Palmer, Raymond D.
Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
title Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
title_full Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
title_fullStr Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
title_full_unstemmed Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
title_short Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
title_sort aging clocks & mortality timers, methylation, glycomic, telomeric and more. a window to measuring biological age
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245174/
https://www.ncbi.nlm.nih.gov/pubmed/35783114
http://dx.doi.org/10.1002/agm2.12197
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