Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma

BACKGROUND: Deletion of 1p is associated with poor prognosis in neuroblastoma, however selected 1p-intact patients still experience poor outcomes. Since mutations of 1p genes may mimic the deleterious effects of chromosomal loss, we studied the incidence, spectrum and effects of mutational variants...

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Detalles Bibliográficos
Autores principales: Kuick, Chik Hong, Tan, Jia Ying, Jasmine, Deborah, Sumanty, Tohari, Ng, Alvin Y. J., Venkatesh, Byrrappa, Chen, Huiyi, Loh, Eva, Jain, Sudhanshi, Seow, Wan Yi, Ng, Eileen H. Q., Lian, Derrick W. Q., Soh, Shui Yen, Chang, Kenneth T. E., Chen, Zhi Xiong, Loh, Amos H. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245282/
https://www.ncbi.nlm.nih.gov/pubmed/35768791
http://dx.doi.org/10.1186/s12885-022-09800-0

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