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Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland

BACKGROUND: HIV infection is associated with an increased risk of morbidity and mortality from vaccine preventable infections. This research describes, in the context of changing patient demographics, the seroprevalence of vaccine preventable viral infections among attendees of the largest centre fo...

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Autores principales: Kerr, C., Kelleher, M., Coughlan, S., Crowley, B., O’Reilly, E. J., Bergin, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245288/
https://www.ncbi.nlm.nih.gov/pubmed/35768790
http://dx.doi.org/10.1186/s12879-022-07487-z
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author Kerr, C.
Kelleher, M.
Coughlan, S.
Crowley, B.
O’Reilly, E. J.
Bergin, C.
author_facet Kerr, C.
Kelleher, M.
Coughlan, S.
Crowley, B.
O’Reilly, E. J.
Bergin, C.
author_sort Kerr, C.
collection PubMed
description BACKGROUND: HIV infection is associated with an increased risk of morbidity and mortality from vaccine preventable infections. This research describes, in the context of changing patient demographics, the seroprevalence of vaccine preventable viral infections among attendees of the largest centre for HIV positive patients in Ireland. METHODS: Baseline serum IgG results for measles, mumps, rubella, varicella zoster virus (VZV) & hepatitis A, as well as hepatitis B sAg, cAb and sAb results, were retrieved for 2534 clinic attendees attending in 2018. Results were available for between 990 and 2363 attendees (39–93%), depending on the test, and were compared with 2013 clinic data. RESULTS: There was a 35% increase in attendees in 2018 when compared to 2013. The largest increase was in attendees of South American origin. In 2018, males accounted for 73% of the entire cohort and the HIV acquisition risk for 48% of attendees was MSM. 47% of attendees were originally from Ireland. Among those tested, 33% were susceptible to at least one component of the MMR vaccine. 5% were VZV non-immune (significantly associated with younger age and the acquisition risk status of injection drug use). 21% were hepatitis A non-immune (significantly associated with younger age and being of European or South American origin). 32% were hepatitis B cAb seropositive (significantly associated with older age, injection drug use status and being originally from Africa). 3% demonstrated hepatitis B sAg positivity. 64% had hepatitis B sAb ≥ 10mIU. CONCLUSION: In a cohort of attendees to an HIV clinic in a large urban setting, the susceptibility to several common vaccine preventable viral infections, in particular MMR and hepatitis A and B, was high. These results highlight the importance of proactive screening and immunisation to help protect this high risk patient group against vaccine preventable diseases.
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spelling pubmed-92452882022-07-01 Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland Kerr, C. Kelleher, M. Coughlan, S. Crowley, B. O’Reilly, E. J. Bergin, C. BMC Infect Dis Research Article BACKGROUND: HIV infection is associated with an increased risk of morbidity and mortality from vaccine preventable infections. This research describes, in the context of changing patient demographics, the seroprevalence of vaccine preventable viral infections among attendees of the largest centre for HIV positive patients in Ireland. METHODS: Baseline serum IgG results for measles, mumps, rubella, varicella zoster virus (VZV) & hepatitis A, as well as hepatitis B sAg, cAb and sAb results, were retrieved for 2534 clinic attendees attending in 2018. Results were available for between 990 and 2363 attendees (39–93%), depending on the test, and were compared with 2013 clinic data. RESULTS: There was a 35% increase in attendees in 2018 when compared to 2013. The largest increase was in attendees of South American origin. In 2018, males accounted for 73% of the entire cohort and the HIV acquisition risk for 48% of attendees was MSM. 47% of attendees were originally from Ireland. Among those tested, 33% were susceptible to at least one component of the MMR vaccine. 5% were VZV non-immune (significantly associated with younger age and the acquisition risk status of injection drug use). 21% were hepatitis A non-immune (significantly associated with younger age and being of European or South American origin). 32% were hepatitis B cAb seropositive (significantly associated with older age, injection drug use status and being originally from Africa). 3% demonstrated hepatitis B sAg positivity. 64% had hepatitis B sAb ≥ 10mIU. CONCLUSION: In a cohort of attendees to an HIV clinic in a large urban setting, the susceptibility to several common vaccine preventable viral infections, in particular MMR and hepatitis A and B, was high. These results highlight the importance of proactive screening and immunisation to help protect this high risk patient group against vaccine preventable diseases. BioMed Central 2022-06-29 /pmc/articles/PMC9245288/ /pubmed/35768790 http://dx.doi.org/10.1186/s12879-022-07487-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Kerr, C.
Kelleher, M.
Coughlan, S.
Crowley, B.
O’Reilly, E. J.
Bergin, C.
Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland
title Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland
title_full Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland
title_fullStr Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland
title_full_unstemmed Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland
title_short Changing demographics and immunity to vaccine preventable diseases in people with HIV in Ireland
title_sort changing demographics and immunity to vaccine preventable diseases in people with hiv in ireland
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245288/
https://www.ncbi.nlm.nih.gov/pubmed/35768790
http://dx.doi.org/10.1186/s12879-022-07487-z
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