Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome

BACKGROUND: Fragile X syndrome (FXS), the most common genetic cause of autism spectrum disorder and intellectual disability, is caused by the lack of fragile X mental retardation protein (FMRP) expression. FMRP is an mRNA binding protein with functions in mRNA transport, localization, and translatio...

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Detalles Bibliográficos
Autores principales: Kalinowska, Magdalena, van der Lei, Mathijs B., Kitiashvili, Michael, Mamcarz, Maggie, Oliveira, Mauricio M., Longo, Francesco, Klann, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245312/
https://www.ncbi.nlm.nih.gov/pubmed/35768828
http://dx.doi.org/10.1186/s13229-022-00509-2

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