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Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study

BACKGROUND: There is a paucity of research describing health‐related quality of life (HRQOL) in older adults considered for advanced heart failure surgical therapies. Using data from our SUSTAIN‐IT (Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support) study, we aimed to co...

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Autores principales: Grady, Kathleen L., Andrei, Adin‐Cristian, Elenbaas, Christian, Warzecha, Anna, Baldridge, Abigail, Kao, Andrew, Spertus, John A., Pham, Duc‐Thinh, Dew, Mary Amanda, Hsich, Eileen, Cotts, William, Hartupee, Justin, Pamboukian, Salpy V., Pagani, Francis D., Petty, Michael, Lampert, Brent, Johnson, Maryl, Murray, Margaret, Takeda, Koji, Yuzefpolskaya, Melana, Silvestry, Scott, Kirklin, James K., Yancy, Clyde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245796/
https://www.ncbi.nlm.nih.gov/pubmed/35156421
http://dx.doi.org/10.1161/JAHA.121.024385
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author Grady, Kathleen L.
Andrei, Adin‐Cristian
Elenbaas, Christian
Warzecha, Anna
Baldridge, Abigail
Kao, Andrew
Spertus, John A.
Pham, Duc‐Thinh
Dew, Mary Amanda
Hsich, Eileen
Cotts, William
Hartupee, Justin
Pamboukian, Salpy V.
Pagani, Francis D.
Petty, Michael
Lampert, Brent
Johnson, Maryl
Murray, Margaret
Takeda, Koji
Yuzefpolskaya, Melana
Silvestry, Scott
Kirklin, James K.
Yancy, Clyde
author_facet Grady, Kathleen L.
Andrei, Adin‐Cristian
Elenbaas, Christian
Warzecha, Anna
Baldridge, Abigail
Kao, Andrew
Spertus, John A.
Pham, Duc‐Thinh
Dew, Mary Amanda
Hsich, Eileen
Cotts, William
Hartupee, Justin
Pamboukian, Salpy V.
Pagani, Francis D.
Petty, Michael
Lampert, Brent
Johnson, Maryl
Murray, Margaret
Takeda, Koji
Yuzefpolskaya, Melana
Silvestry, Scott
Kirklin, James K.
Yancy, Clyde
author_sort Grady, Kathleen L.
collection PubMed
description BACKGROUND: There is a paucity of research describing health‐related quality of life (HRQOL) in older adults considered for advanced heart failure surgical therapies. Using data from our SUSTAIN‐IT (Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support) study, we aimed to compare HRQOL among 3 groups of older (60–80 years) patients with heart failure before heart transplantation (HT) or long‐term mechanical circulatory support (MCS) and identify factors associated with HRQOL: (1) HT candidates with MCS, (2) HT candidates without MCS, or (3) candidates ineligible for HT and scheduled for long‐term MCS. METHODS AND RESULTS: Patients from 13 US sites completed assessments, including self‐reported measures of HRQOL (EuroQol‐5 Dimension Questionnaire, Kansas City Cardiomyopathy Questionnaire–12), depressive symptoms (Personal Health Questionnaire–8), anxiety (State‐Trait Anxiety Inventory–state form), cognitive status (Montreal Cognitive Assessment), and performance‐based measures (6‐minute walk test and 5‐m gait speed). Analyses included ANOVA, χ(2) tests, Fisher’s exact tests, and linear regression. The sample included 393 patients; the majority of patients were White men and married. Long‐term MCS candidates (n=154) were significantly older and had more comorbidities and a higher New York Heart Association class than HT candidates with MCS (n=118) and HT candidates without MCS (n=121). Long‐term MCS candidates had worse HRQOL than HT candidates with and without MCS (EQ‐5D visual analog scale scores, 46±23 versus 68±18 versus 54±23 [P<0.001] and Kansas City Cardiomyopathy Questionnaire–12 overall summary scores, 35±21 versus 60±21 versus 49±22 [P<0.001], respectively). In multivariable analyses, lower 6‐minute walk distance, higher New York Heart Association class, depressive symptoms, and not being an HT candidate with MCS were significantly associated with worse overall HRQOL. CONCLUSIONS: Our findings demonstrate important differences in overall and domain‐specific HRQOL of older patients with heart failure before HT or long‐term MCS. Understanding HRQOL differences may guide decisions toward more appropriate and personalized advanced heart failure therapies.
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spelling pubmed-92457962022-07-01 Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study Grady, Kathleen L. Andrei, Adin‐Cristian Elenbaas, Christian Warzecha, Anna Baldridge, Abigail Kao, Andrew Spertus, John A. Pham, Duc‐Thinh Dew, Mary Amanda Hsich, Eileen Cotts, William Hartupee, Justin Pamboukian, Salpy V. Pagani, Francis D. Petty, Michael Lampert, Brent Johnson, Maryl Murray, Margaret Takeda, Koji Yuzefpolskaya, Melana Silvestry, Scott Kirklin, James K. Yancy, Clyde J Am Heart Assoc Original Research BACKGROUND: There is a paucity of research describing health‐related quality of life (HRQOL) in older adults considered for advanced heart failure surgical therapies. Using data from our SUSTAIN‐IT (Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support) study, we aimed to compare HRQOL among 3 groups of older (60–80 years) patients with heart failure before heart transplantation (HT) or long‐term mechanical circulatory support (MCS) and identify factors associated with HRQOL: (1) HT candidates with MCS, (2) HT candidates without MCS, or (3) candidates ineligible for HT and scheduled for long‐term MCS. METHODS AND RESULTS: Patients from 13 US sites completed assessments, including self‐reported measures of HRQOL (EuroQol‐5 Dimension Questionnaire, Kansas City Cardiomyopathy Questionnaire–12), depressive symptoms (Personal Health Questionnaire–8), anxiety (State‐Trait Anxiety Inventory–state form), cognitive status (Montreal Cognitive Assessment), and performance‐based measures (6‐minute walk test and 5‐m gait speed). Analyses included ANOVA, χ(2) tests, Fisher’s exact tests, and linear regression. The sample included 393 patients; the majority of patients were White men and married. Long‐term MCS candidates (n=154) were significantly older and had more comorbidities and a higher New York Heart Association class than HT candidates with MCS (n=118) and HT candidates without MCS (n=121). Long‐term MCS candidates had worse HRQOL than HT candidates with and without MCS (EQ‐5D visual analog scale scores, 46±23 versus 68±18 versus 54±23 [P<0.001] and Kansas City Cardiomyopathy Questionnaire–12 overall summary scores, 35±21 versus 60±21 versus 49±22 [P<0.001], respectively). In multivariable analyses, lower 6‐minute walk distance, higher New York Heart Association class, depressive symptoms, and not being an HT candidate with MCS were significantly associated with worse overall HRQOL. CONCLUSIONS: Our findings demonstrate important differences in overall and domain‐specific HRQOL of older patients with heart failure before HT or long‐term MCS. Understanding HRQOL differences may guide decisions toward more appropriate and personalized advanced heart failure therapies. John Wiley and Sons Inc. 2022-02-12 /pmc/articles/PMC9245796/ /pubmed/35156421 http://dx.doi.org/10.1161/JAHA.121.024385 Text en © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Grady, Kathleen L.
Andrei, Adin‐Cristian
Elenbaas, Christian
Warzecha, Anna
Baldridge, Abigail
Kao, Andrew
Spertus, John A.
Pham, Duc‐Thinh
Dew, Mary Amanda
Hsich, Eileen
Cotts, William
Hartupee, Justin
Pamboukian, Salpy V.
Pagani, Francis D.
Petty, Michael
Lampert, Brent
Johnson, Maryl
Murray, Margaret
Takeda, Koji
Yuzefpolskaya, Melana
Silvestry, Scott
Kirklin, James K.
Yancy, Clyde
Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study
title Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study
title_full Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study
title_fullStr Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study
title_full_unstemmed Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study
title_short Health‐Related Quality of Life in Older Patients With Advanced Heart Failure: Findings From the SUSTAIN‐IT Study
title_sort health‐related quality of life in older patients with advanced heart failure: findings from the sustain‐it study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245796/
https://www.ncbi.nlm.nih.gov/pubmed/35156421
http://dx.doi.org/10.1161/JAHA.121.024385
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