Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is a lethal disease driven by myofibroblast expansion. Currently no therapies exist that target the epigenetic mechanisms controlling myofibroblast transdifferentiation, which is responsible for unregulated extracellular matrix (ECM) production. We have recently shown t...

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Detalles Bibliográficos
Autores principales: Bernau, Ksenija, Skibba, Melissa, Leet, Jonathan P., Furey, Sierra, Gehl, Carson, Li, Yi, Zhou, Jia, Sandbo, Nathan, Brasier, Allan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245900/
https://www.ncbi.nlm.nih.gov/pubmed/35782526
http://dx.doi.org/10.3389/fmmed.2022.842558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245900/
https://www.ncbi.nlm.nih.gov/pubmed/35782526
http://dx.doi.org/10.3389/fmmed.2022.842558

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