Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors

Galectins are galactoside-binding proteins that play a role in various pathophysiological conditions, making them attractive targets in drug discovery. We have designed and synthesised a focused library of aromatic 3-triazolyl-1-thiogalactosides targeting their core site for binding of galactose and...

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Detalles Bibliográficos
Autores principales: van Klaveren, Sjors, Dernovšek, Jaka, Jakopin, Žiga, Anderluh, Marko, Leffler, Hakon, Nilsson, Ulf J., Tomašič, Tihomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245910/
https://www.ncbi.nlm.nih.gov/pubmed/35873334
http://dx.doi.org/10.1039/d2ra03163a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245910/
https://www.ncbi.nlm.nih.gov/pubmed/35873334
http://dx.doi.org/10.1039/d2ra03163a

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