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ECM1 is associated with endocrine resistance in ER(+) breast cancers
Extracellular matrix protein 1 (ECM1) is associated with a poor prognosis of breast cancers. However, the role of ECM1 with endocrine resistance in estrogen receptor-positive (ER(+)) breast cancers has not been elucidated yet. We show that ECM1 promotes endocrine resistance in ER(+) breast cancers....
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246032/ https://www.ncbi.nlm.nih.gov/pubmed/35784388 http://dx.doi.org/10.1080/19768354.2022.2083235 |
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author | Lee, Tae Won Lee, Kyung-min |
author_facet | Lee, Tae Won Lee, Kyung-min |
author_sort | Lee, Tae Won |
collection | PubMed |
description | Extracellular matrix protein 1 (ECM1) is associated with a poor prognosis of breast cancers. However, the role of ECM1 with endocrine resistance in estrogen receptor-positive (ER(+)) breast cancers has not been elucidated yet. We show that ECM1 promotes endocrine resistance in ER(+) breast cancers. ECM1 is overexpressed in luminal breast cancer patients compared to the basal type of breast cancer. Significantly, higher expression of ECM1 is associated with poor response to endocrine therapies in luminal B breast cancer patients. We found that ECM1 is upregulated in CAMA1 and MDA-MB-361 cells grown in long-term estrogen-deprived (LTED) conditions. Moreover, the ablation of ECM1 significantly inhibited the proliferation of CAMA1 LTED and MDA-MB-361 LTED cells. Finally, an interrogation of a dataset containing transcriptome and proteome of breast cancer cell lines revealed that the level of ECM1 mRNA is positively correlated with that of phosphorylated Src. Based on these findings, we strongly suggest that ECM1 significantly contributes to the acquisition of endocrine resistance in ER(+) breast cancers by the activation of Src. |
format | Online Article Text |
id | pubmed-9246032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-92460322022-07-01 ECM1 is associated with endocrine resistance in ER(+) breast cancers Lee, Tae Won Lee, Kyung-min Anim Cells Syst (Seoul) Translational Medicine Extracellular matrix protein 1 (ECM1) is associated with a poor prognosis of breast cancers. However, the role of ECM1 with endocrine resistance in estrogen receptor-positive (ER(+)) breast cancers has not been elucidated yet. We show that ECM1 promotes endocrine resistance in ER(+) breast cancers. ECM1 is overexpressed in luminal breast cancer patients compared to the basal type of breast cancer. Significantly, higher expression of ECM1 is associated with poor response to endocrine therapies in luminal B breast cancer patients. We found that ECM1 is upregulated in CAMA1 and MDA-MB-361 cells grown in long-term estrogen-deprived (LTED) conditions. Moreover, the ablation of ECM1 significantly inhibited the proliferation of CAMA1 LTED and MDA-MB-361 LTED cells. Finally, an interrogation of a dataset containing transcriptome and proteome of breast cancer cell lines revealed that the level of ECM1 mRNA is positively correlated with that of phosphorylated Src. Based on these findings, we strongly suggest that ECM1 significantly contributes to the acquisition of endocrine resistance in ER(+) breast cancers by the activation of Src. Taylor & Francis 2022-06-22 /pmc/articles/PMC9246032/ /pubmed/35784388 http://dx.doi.org/10.1080/19768354.2022.2083235 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Translational Medicine Lee, Tae Won Lee, Kyung-min ECM1 is associated with endocrine resistance in ER(+) breast cancers |
title | ECM1 is associated with endocrine resistance in ER(+) breast cancers |
title_full | ECM1 is associated with endocrine resistance in ER(+) breast cancers |
title_fullStr | ECM1 is associated with endocrine resistance in ER(+) breast cancers |
title_full_unstemmed | ECM1 is associated with endocrine resistance in ER(+) breast cancers |
title_short | ECM1 is associated with endocrine resistance in ER(+) breast cancers |
title_sort | ecm1 is associated with endocrine resistance in er(+) breast cancers |
topic | Translational Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246032/ https://www.ncbi.nlm.nih.gov/pubmed/35784388 http://dx.doi.org/10.1080/19768354.2022.2083235 |
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