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MicroRNA-4516 suppresses proliferative vitreoretinopathy development via negatively regulating OTX1

Proliferative vitreoretinopathy (PVR) progression is associated with TGF-β2-induced epithelial–mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells. In cancer cells, miR-4516 downregulates orthodenticle homeobox 1 (OTX1)-mediated cell invasion. Moreover, OTX1 is shown to be involve...

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Detalles Bibliográficos
Autores principales:	Pao, Shu-I, Lin, Le-Tien, Chen, Yi-Hao, Chen, Ching-Long, Chen, Jiann-Torng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246108/ https://www.ncbi.nlm.nih.gov/pubmed/35771766 http://dx.doi.org/10.1371/journal.pone.0270526

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