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Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?

Symptom profiles have previously been identified for infectious intestinal disease (IID) which distinguish bacterial from viral organisms. However, there is evidence that the seasonality, severity, and duration of IID may differ between children, adults and elderly. A secondary data analysis was und...

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Autores principales: Donaldson, Anna L., Harris, John P., Vivancos, Roberto, O’Brien, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246150/
https://www.ncbi.nlm.nih.gov/pubmed/35771750
http://dx.doi.org/10.1371/journal.pone.0269676
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author Donaldson, Anna L.
Harris, John P.
Vivancos, Roberto
O’Brien, Sarah J.
author_facet Donaldson, Anna L.
Harris, John P.
Vivancos, Roberto
O’Brien, Sarah J.
author_sort Donaldson, Anna L.
collection PubMed
description Symptom profiles have previously been identified for infectious intestinal disease (IID) which distinguish bacterial from viral organisms. However, there is evidence that the seasonality, severity, and duration of IID may differ between children, adults and elderly. A secondary data analysis was undertaken to explore whether symptom profiles for bacterial and viral IID vary across different age groups. Data from 844 cases of IID were divided into three age categories: <16 years, 16–65 years and >65 years. Multivariable logistic regression modelling was used to compare the significance of different symptoms across the three age groups. The odds of bacterial IID in children were increased by onset in the summer, diarrhoea in the absence of vomiting and fever. These symptoms were also associated with lower odds of a viral pathogen. In adults, diarrhoea but no vomiting, bloody diarrhoea and diarrhoea lasting more than 3 days were associated with increased odds of a bacterial organism, whilst onset in the winter or spring and a loss of appetite were associated with viral IID. In the elderly, diarrhoea in the absence of vomiting and diarrhoea lasting more than 3 days were associated with higher odds of bacterial IID and lower odds of a viral cause. Only diarrhoea in the absence of vomiting emerged as a key symptom across all three age groups. Variation in symptom profiles by age has implications for clinicians, public health specialists and epidemiologists who use symptoms to guide presumptive diagnoses in the absence of microbiological confirmation.
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spelling pubmed-92461502022-07-01 Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age? Donaldson, Anna L. Harris, John P. Vivancos, Roberto O’Brien, Sarah J. PLoS One Research Article Symptom profiles have previously been identified for infectious intestinal disease (IID) which distinguish bacterial from viral organisms. However, there is evidence that the seasonality, severity, and duration of IID may differ between children, adults and elderly. A secondary data analysis was undertaken to explore whether symptom profiles for bacterial and viral IID vary across different age groups. Data from 844 cases of IID were divided into three age categories: <16 years, 16–65 years and >65 years. Multivariable logistic regression modelling was used to compare the significance of different symptoms across the three age groups. The odds of bacterial IID in children were increased by onset in the summer, diarrhoea in the absence of vomiting and fever. These symptoms were also associated with lower odds of a viral pathogen. In adults, diarrhoea but no vomiting, bloody diarrhoea and diarrhoea lasting more than 3 days were associated with increased odds of a bacterial organism, whilst onset in the winter or spring and a loss of appetite were associated with viral IID. In the elderly, diarrhoea in the absence of vomiting and diarrhoea lasting more than 3 days were associated with higher odds of bacterial IID and lower odds of a viral cause. Only diarrhoea in the absence of vomiting emerged as a key symptom across all three age groups. Variation in symptom profiles by age has implications for clinicians, public health specialists and epidemiologists who use symptoms to guide presumptive diagnoses in the absence of microbiological confirmation. Public Library of Science 2022-06-30 /pmc/articles/PMC9246150/ /pubmed/35771750 http://dx.doi.org/10.1371/journal.pone.0269676 Text en © 2022 Donaldson et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Donaldson, Anna L.
Harris, John P.
Vivancos, Roberto
O’Brien, Sarah J.
Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?
title Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?
title_full Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?
title_fullStr Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?
title_full_unstemmed Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?
title_short Symptom profiling for infectious intestinal disease (IID): Do symptom profiles alter with age?
title_sort symptom profiling for infectious intestinal disease (iid): do symptom profiles alter with age?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246150/
https://www.ncbi.nlm.nih.gov/pubmed/35771750
http://dx.doi.org/10.1371/journal.pone.0269676
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