Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis

OBJECTIVES: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance METHODS: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected...

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Detalles Bibliográficos
Autores principales: Soydal, Çiğdem, Araz, Mine, Durmaz, Mustafa, Özkan, Elgin, Ergüder, Berrin İmge, Küçük, Nuriye Özlem, Bilgiç, Sadık, Elhan, Atilla Halil, Geçim, İbrahim Ethem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246306/
https://www.ncbi.nlm.nih.gov/pubmed/35770977
http://dx.doi.org/10.4274/mirt.galenos.2022.73636
Descripción
Sumario:OBJECTIVES: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance METHODS: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients. RESULTS: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1(st) week and vascular endothelial growth factor (VEGF) levels in the 6(th) week after TARE had significantly shorter median overall survival (OS) times. CONCLUSION: Some early increases in serum angiogenic factor levels and in serum VEGF in the 6(th) week after TARE for CRCLMs are related to short OS and progression-free survival.

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