Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis

OBJECTIVES: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance METHODS: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected...

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Autores principales: Soydal, Çiğdem, Araz, Mine, Durmaz, Mustafa, Özkan, Elgin, Ergüder, Berrin İmge, Küçük, Nuriye Özlem, Bilgiç, Sadık, Elhan, Atilla Halil, Geçim, İbrahim Ethem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246306/
https://www.ncbi.nlm.nih.gov/pubmed/35770977
http://dx.doi.org/10.4274/mirt.galenos.2022.73636
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author Soydal, Çiğdem
Araz, Mine
Durmaz, Mustafa
Özkan, Elgin
Ergüder, Berrin İmge
Küçük, Nuriye Özlem
Bilgiç, Sadık
Elhan, Atilla Halil
Geçim, İbrahim Ethem
author_facet Soydal, Çiğdem
Araz, Mine
Durmaz, Mustafa
Özkan, Elgin
Ergüder, Berrin İmge
Küçük, Nuriye Özlem
Bilgiç, Sadık
Elhan, Atilla Halil
Geçim, İbrahim Ethem
author_sort Soydal, Çiğdem
collection PubMed
description OBJECTIVES: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance METHODS: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients. RESULTS: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1(st) week and vascular endothelial growth factor (VEGF) levels in the 6(th) week after TARE had significantly shorter median overall survival (OS) times. CONCLUSION: Some early increases in serum angiogenic factor levels and in serum VEGF in the 6(th) week after TARE for CRCLMs are related to short OS and progression-free survival.
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spelling pubmed-92463062022-07-13 Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis Soydal, Çiğdem Araz, Mine Durmaz, Mustafa Özkan, Elgin Ergüder, Berrin İmge Küçük, Nuriye Özlem Bilgiç, Sadık Elhan, Atilla Halil Geçim, İbrahim Ethem Mol Imaging Radionucl Ther Original Article OBJECTIVES: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance METHODS: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients. RESULTS: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1(st) week and vascular endothelial growth factor (VEGF) levels in the 6(th) week after TARE had significantly shorter median overall survival (OS) times. CONCLUSION: Some early increases in serum angiogenic factor levels and in serum VEGF in the 6(th) week after TARE for CRCLMs are related to short OS and progression-free survival. Galenos Publishing 2022-06 2022-06-27 /pmc/articles/PMC9246306/ /pubmed/35770977 http://dx.doi.org/10.4274/mirt.galenos.2022.73636 Text en ©Copyright 2022 by Turkish Society of Nuclear Medicine | Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Soydal, Çiğdem
Araz, Mine
Durmaz, Mustafa
Özkan, Elgin
Ergüder, Berrin İmge
Küçük, Nuriye Özlem
Bilgiç, Sadık
Elhan, Atilla Halil
Geçim, İbrahim Ethem
Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis
title Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis
title_full Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis
title_fullStr Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis
title_full_unstemmed Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis
title_short Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis
title_sort elevated angiogenic factor levels after transarterial radioembolization for colorectal cancer liver metastases may predict a poor prognosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246306/
https://www.ncbi.nlm.nih.gov/pubmed/35770977
http://dx.doi.org/10.4274/mirt.galenos.2022.73636
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