Cargando…

Towards ‘end-to-end’ analysis and understanding of biological timecourse data

Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Jena, Siddhartha G., Goglia, Alexander G., Engelhardt, Barbara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246344/
https://www.ncbi.nlm.nih.gov/pubmed/35713413
http://dx.doi.org/10.1042/BCJ20220053
Descripción
Sumario:Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, the current modalities for analysis and mining of these data are scattered and user-specific, preventing more unified analyses from being performed over different datasets and obscuring possible scientific insights. Here, we propose a unified pipeline for storage, segmentation, analysis, and statistical parametrization of live cell imaging datasets.