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Towards ‘end-to-end’ analysis and understanding of biological timecourse data
Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246344/ https://www.ncbi.nlm.nih.gov/pubmed/35713413 http://dx.doi.org/10.1042/BCJ20220053 |
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author | Jena, Siddhartha G. Goglia, Alexander G. Engelhardt, Barbara E. |
author_facet | Jena, Siddhartha G. Goglia, Alexander G. Engelhardt, Barbara E. |
author_sort | Jena, Siddhartha G. |
collection | PubMed |
description | Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, the current modalities for analysis and mining of these data are scattered and user-specific, preventing more unified analyses from being performed over different datasets and obscuring possible scientific insights. Here, we propose a unified pipeline for storage, segmentation, analysis, and statistical parametrization of live cell imaging datasets. |
format | Online Article Text |
id | pubmed-9246344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92463442022-07-12 Towards ‘end-to-end’ analysis and understanding of biological timecourse data Jena, Siddhartha G. Goglia, Alexander G. Engelhardt, Barbara E. Biochem J Computational Biology Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, the current modalities for analysis and mining of these data are scattered and user-specific, preventing more unified analyses from being performed over different datasets and obscuring possible scientific insights. Here, we propose a unified pipeline for storage, segmentation, analysis, and statistical parametrization of live cell imaging datasets. Portland Press Ltd. 2022-06-17 /pmc/articles/PMC9246344/ /pubmed/35713413 http://dx.doi.org/10.1042/BCJ20220053 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Computational Biology Jena, Siddhartha G. Goglia, Alexander G. Engelhardt, Barbara E. Towards ‘end-to-end’ analysis and understanding of biological timecourse data |
title | Towards ‘end-to-end’ analysis and understanding of biological timecourse data |
title_full | Towards ‘end-to-end’ analysis and understanding of biological timecourse data |
title_fullStr | Towards ‘end-to-end’ analysis and understanding of biological timecourse data |
title_full_unstemmed | Towards ‘end-to-end’ analysis and understanding of biological timecourse data |
title_short | Towards ‘end-to-end’ analysis and understanding of biological timecourse data |
title_sort | towards ‘end-to-end’ analysis and understanding of biological timecourse data |
topic | Computational Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246344/ https://www.ncbi.nlm.nih.gov/pubmed/35713413 http://dx.doi.org/10.1042/BCJ20220053 |
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