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Towards ‘end-to-end’ analysis and understanding of biological timecourse data

Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, t...

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Detalles Bibliográficos
Autores principales: Jena, Siddhartha G., Goglia, Alexander G., Engelhardt, Barbara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246344/
https://www.ncbi.nlm.nih.gov/pubmed/35713413
http://dx.doi.org/10.1042/BCJ20220053
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author Jena, Siddhartha G.
Goglia, Alexander G.
Engelhardt, Barbara E.
author_facet Jena, Siddhartha G.
Goglia, Alexander G.
Engelhardt, Barbara E.
author_sort Jena, Siddhartha G.
collection PubMed
description Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, the current modalities for analysis and mining of these data are scattered and user-specific, preventing more unified analyses from being performed over different datasets and obscuring possible scientific insights. Here, we propose a unified pipeline for storage, segmentation, analysis, and statistical parametrization of live cell imaging datasets.
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spelling pubmed-92463442022-07-12 Towards ‘end-to-end’ analysis and understanding of biological timecourse data Jena, Siddhartha G. Goglia, Alexander G. Engelhardt, Barbara E. Biochem J Computational Biology Petabytes of increasingly complex and multidimensional live cell and tissue imaging data are generated every year. These videos hold large promise for understanding biology at a deep and fundamental level, as they capture single-cell and multicellular events occurring over time and space. However, the current modalities for analysis and mining of these data are scattered and user-specific, preventing more unified analyses from being performed over different datasets and obscuring possible scientific insights. Here, we propose a unified pipeline for storage, segmentation, analysis, and statistical parametrization of live cell imaging datasets. Portland Press Ltd. 2022-06-17 /pmc/articles/PMC9246344/ /pubmed/35713413 http://dx.doi.org/10.1042/BCJ20220053 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Computational Biology
Jena, Siddhartha G.
Goglia, Alexander G.
Engelhardt, Barbara E.
Towards ‘end-to-end’ analysis and understanding of biological timecourse data
title Towards ‘end-to-end’ analysis and understanding of biological timecourse data
title_full Towards ‘end-to-end’ analysis and understanding of biological timecourse data
title_fullStr Towards ‘end-to-end’ analysis and understanding of biological timecourse data
title_full_unstemmed Towards ‘end-to-end’ analysis and understanding of biological timecourse data
title_short Towards ‘end-to-end’ analysis and understanding of biological timecourse data
title_sort towards ‘end-to-end’ analysis and understanding of biological timecourse data
topic Computational Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246344/
https://www.ncbi.nlm.nih.gov/pubmed/35713413
http://dx.doi.org/10.1042/BCJ20220053
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