High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy

Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich Proteins 2 and 3 (HRP2 and HRP3). Deletions of the hrp2 and hrp3 genes result in false-negative tests and are a threat for malaria control. A novel assay for molecular surveillance of hrp2/hrp3 deletions was deve...

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Detalles Bibliográficos
Autores principales: Vera-Arias, Claudia A, Holzschuh, Aurel, Oduma, Colins O, Badu, Kingsley, Abdul-Hakim, Mutala, Yukich, Joshua, Hetzel, Manuel W, Fakih, Bakar S, Ali, Abdullah, Ferreira, Marcelo U, Ladeia-Andrade, Simone, Sáenz, Fabián E, Afrane, Yaw, Zemene, Endalew, Yewhalaw, Delenasaw, Kazura, James W, Yan, Guiyun, Koepfli, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246365/
https://www.ncbi.nlm.nih.gov/pubmed/35762586
http://dx.doi.org/10.7554/eLife.72083

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