A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPR(mt)), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of a ubiquitous UPR(mt) to promote prostate ca...

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Detalles Bibliográficos
Autores principales: Kumar, Rahul, Chaudhary, Ajay K., Woytash, Jordan, Inigo, Joseph R., Gokhale, Abhiram A., Bshara, Wiam, Attwood, Kristopher, Wang, Jianmin, Spernyak, Joseph A., Rath, Eva, Yadav, Neelu, Haller, Dirk, Goodrich, David W., Tang, Dean G., Chandra, Dhyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246382/
https://www.ncbi.nlm.nih.gov/pubmed/35653190
http://dx.doi.org/10.1172/JCI149906

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