Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4

Lymph node (LN) fibroblastic reticular cells (FRCs) define LN niches and regulate lymphocyte homeostasis through producing diverse extracellular matrix (ECM) components. We examined the role of ECM laminin α4 (Lama4) using FRC-Lama4 conditional KO Pdgfrb-Cre(–/–) × Lama4(fl/fl) mice. Single-cell RNA...

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Detalles Bibliográficos
Autores principales: Li, Lushen, Shirkey, Marina W., Zhang, Tianshu, Piao, Wenji, Li, Xiaofei, Zhao, Jing, Mei, Zhongcheng, Guo, Yizhan, Saxena, Vikas, Kensiski, Allison, Gavzy, Samuel J., Song, Yang, Ma, Bing, Wu, Jing, Xiong, Yanbao, Wu, Long, Fan, Xiaoxuan, Roussey, Holly, Li, Meng, Krupnick, Alexæander S., Abdi, Reza, Bromberg, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246384/
https://www.ncbi.nlm.nih.gov/pubmed/35775481
http://dx.doi.org/10.1172/JCI156994

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