LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade

The inability of CD8(+) effector T cells (Teffs) to reach tumor cells is an important aspect of tumor resistance to cancer immunotherapy. The recruitment of these cells to the tumor microenvironment (TME) is regulated by integrins, a family of adhesion molecules that are expressed on T cells. Here,...

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Detalles Bibliográficos
Autores principales: Hickman, Amber, Koetsier, Joost, Kurtanich, Trevin, Nielsen, Michael C., Winn, Glenn, Wang, Yunfei, Bentebibel, Salah-Eddine, Shi, Leilei, Punt, Simone, Williams, Leila, Haymaker, Cara, Chesson, Charles B., Fa’ak, Faisal, Dominguez, Ana L., Jones, Richard, Kuiatse, Isere, Caivano, Amy R., Khounlo, Sayadeth, Warier, Navin D., Marathi, Upendra, Market, Robert V., Biediger, Ronald J., Craft, John W., Hwu, Patrick, Davies, Michael A., Woodside, Darren G., Vanderslice, Peter, Diab, Adi, Overwijk, Willem W., Hailemichael, Yared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246385/
https://www.ncbi.nlm.nih.gov/pubmed/35552271
http://dx.doi.org/10.1172/JCI154152

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