ID2 and HIF-1α collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion

Defining mechanism(s) that maintain tissue stem quiescence is important for improving tissue regeneration, cell therapies, aging, and cancer. We report here that genetic ablation of Id2 in adult hematopoietic stem cells (HSCs) promotes increased HSC activation and differentiation, which results in H...

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Detalles Bibliográficos
Autores principales: Jakubison, Brad L., Sarkar, Tanmoy, Gudmundsson, Kristbjorn O., Singh, Shweta, Sun, Lei, Morris, Holly M., Klarmann, Kimberly D., Keller, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246389/
https://www.ncbi.nlm.nih.gov/pubmed/35775482
http://dx.doi.org/10.1172/JCI152599

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