Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis

We present a case of a 53-year-old black male with a past medical history of type 2 diabetes presenting with fatigue, generalized myalgias, and unintentional weight loss developed over several months. The patient was diagnosed with cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-positive va...

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Detalles Bibliográficos
Autores principales: Crowe, Timothy P, Campos, Roberto, Pereira-Duque, Juan, Samiullah, Mohammad, Eftikari, Perham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246434/
https://www.ncbi.nlm.nih.gov/pubmed/35800827
http://dx.doi.org/10.7759/cureus.25501
Descripción
Sumario:We present a case of a 53-year-old black male with a past medical history of type 2 diabetes presenting with fatigue, generalized myalgias, and unintentional weight loss developed over several months. The patient was diagnosed with cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-positive vasculitis. Renal biopsy confirmed antineutrophil cytoplasmic antibody (ANCA) crescentic necrotizing glomerulonephritis. c-ANCA was positive by enzyme-linked immunosorbent assay. Anti-myeloperoxidase antibody was positive. Without paranasal or lung involvement, the diagnosis was made of renal-limited necrotizing and crescentic glomerulonephritis. The patient was treated with rituximab and prednisone therapy.

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