Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis

We present a case of a 53-year-old black male with a past medical history of type 2 diabetes presenting with fatigue, generalized myalgias, and unintentional weight loss developed over several months. The patient was diagnosed with cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-positive va...

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Detalles Bibliográficos
Autores principales: Crowe, Timothy P, Campos, Roberto, Pereira-Duque, Juan, Samiullah, Mohammad, Eftikari, Perham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246434/
https://www.ncbi.nlm.nih.gov/pubmed/35800827
http://dx.doi.org/10.7759/cureus.25501
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author Crowe, Timothy P
Campos, Roberto
Pereira-Duque, Juan
Samiullah, Mohammad
Eftikari, Perham
author_facet Crowe, Timothy P
Campos, Roberto
Pereira-Duque, Juan
Samiullah, Mohammad
Eftikari, Perham
author_sort Crowe, Timothy P
collection PubMed
description We present a case of a 53-year-old black male with a past medical history of type 2 diabetes presenting with fatigue, generalized myalgias, and unintentional weight loss developed over several months. The patient was diagnosed with cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-positive vasculitis. Renal biopsy confirmed antineutrophil cytoplasmic antibody (ANCA) crescentic necrotizing glomerulonephritis. c-ANCA was positive by enzyme-linked immunosorbent assay. Anti-myeloperoxidase antibody was positive. Without paranasal or lung involvement, the diagnosis was made of renal-limited necrotizing and crescentic glomerulonephritis. The patient was treated with rituximab and prednisone therapy.
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spelling pubmed-92464342022-07-06 Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis Crowe, Timothy P Campos, Roberto Pereira-Duque, Juan Samiullah, Mohammad Eftikari, Perham Cureus Internal Medicine We present a case of a 53-year-old black male with a past medical history of type 2 diabetes presenting with fatigue, generalized myalgias, and unintentional weight loss developed over several months. The patient was diagnosed with cytoplasmic antineutrophil cytoplasmic antibody (c-ANCA)-positive vasculitis. Renal biopsy confirmed antineutrophil cytoplasmic antibody (ANCA) crescentic necrotizing glomerulonephritis. c-ANCA was positive by enzyme-linked immunosorbent assay. Anti-myeloperoxidase antibody was positive. Without paranasal or lung involvement, the diagnosis was made of renal-limited necrotizing and crescentic glomerulonephritis. The patient was treated with rituximab and prednisone therapy. Cureus 2022-05-30 /pmc/articles/PMC9246434/ /pubmed/35800827 http://dx.doi.org/10.7759/cureus.25501 Text en Copyright © 2022, Crowe et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Crowe, Timothy P
Campos, Roberto
Pereira-Duque, Juan
Samiullah, Mohammad
Eftikari, Perham
Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis
title Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis
title_full Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis
title_fullStr Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis
title_full_unstemmed Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis
title_short Suspicion Is Key: Diagnosing Elusive Cytoplasmic Antineutrophil Cytoplasmic Antibody (c-ANCA)-Positive Vasculitis
title_sort suspicion is key: diagnosing elusive cytoplasmic antineutrophil cytoplasmic antibody (c-anca)-positive vasculitis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246434/
https://www.ncbi.nlm.nih.gov/pubmed/35800827
http://dx.doi.org/10.7759/cureus.25501
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