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Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contra...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246578/ https://www.ncbi.nlm.nih.gov/pubmed/35785146 http://dx.doi.org/10.1155/2022/3111054 |
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author | Gu, Peng |
author_facet | Gu, Peng |
author_sort | Gu, Peng |
collection | PubMed |
description | This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scans were performed to determine the shape, scope, and enhancement characteristics of prostate lesions and their relationship with surrounding tissues. The quantitative parameters of ADC and DCE-MRI were measured. There were 4 patients (6.67%) with a Gleason score of 6 and 15 patients (25%) with a 4 + 3 score. The ADC with Gleason = 6 is 0.81 ± 0.08 × 10(−3) s/mm(2), the ADC with Gleason = 3 + 4 is 0.74 ± 0.07 × 10(−3) s/mm(2), the ADC with Gleason = 4 + 3 is 0.73 ± 0.05 × 10(−3) s/mm(2), the ADC with Gleason = 9 is 0.65 ± 0.06 × 10(−3) s/mm(2), and the ADC with Gleason = 10 is 0.59 ± 0.07 × 10(−3) s/mm(2). As the Gleason score increased, the ADC decreased and the permeation parameter transfer constant increased. When the ADC was combined with the permeability parameter transfer constant, the AUC of Gleason = 6 points and Gleason = 7 points was greatly different (P < 0.05). The 95% CI of the ADC combined permeability parameter transport constant when Gleason = 6 points and Gleason = 7 points was 0.898-0.934, the sensitivity was 75.4%, and the specificity was 86.2%. The ADC value was negatively correlated with Gleason score. The ADC value combined with VTC value has good diagnostic performance in evaluating the invasion of PCa, which is very important for making treatment plan and evaluating prognosis. |
format | Online Article Text |
id | pubmed-9246578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92465782022-07-01 Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging Gu, Peng Comput Math Methods Med Research Article This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scans were performed to determine the shape, scope, and enhancement characteristics of prostate lesions and their relationship with surrounding tissues. The quantitative parameters of ADC and DCE-MRI were measured. There were 4 patients (6.67%) with a Gleason score of 6 and 15 patients (25%) with a 4 + 3 score. The ADC with Gleason = 6 is 0.81 ± 0.08 × 10(−3) s/mm(2), the ADC with Gleason = 3 + 4 is 0.74 ± 0.07 × 10(−3) s/mm(2), the ADC with Gleason = 4 + 3 is 0.73 ± 0.05 × 10(−3) s/mm(2), the ADC with Gleason = 9 is 0.65 ± 0.06 × 10(−3) s/mm(2), and the ADC with Gleason = 10 is 0.59 ± 0.07 × 10(−3) s/mm(2). As the Gleason score increased, the ADC decreased and the permeation parameter transfer constant increased. When the ADC was combined with the permeability parameter transfer constant, the AUC of Gleason = 6 points and Gleason = 7 points was greatly different (P < 0.05). The 95% CI of the ADC combined permeability parameter transport constant when Gleason = 6 points and Gleason = 7 points was 0.898-0.934, the sensitivity was 75.4%, and the specificity was 86.2%. The ADC value was negatively correlated with Gleason score. The ADC value combined with VTC value has good diagnostic performance in evaluating the invasion of PCa, which is very important for making treatment plan and evaluating prognosis. Hindawi 2022-06-23 /pmc/articles/PMC9246578/ /pubmed/35785146 http://dx.doi.org/10.1155/2022/3111054 Text en Copyright © 2022 Peng Gu. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gu, Peng Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging |
title | Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging |
title_full | Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging |
title_fullStr | Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging |
title_full_unstemmed | Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging |
title_short | Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging |
title_sort | analysis of apparent diffusion coefficient value and dynamic contrast-enhanced magnetic resonance imaging parameters of prostate cancer patients after diagnosis and treatment with magnetic resonance imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246578/ https://www.ncbi.nlm.nih.gov/pubmed/35785146 http://dx.doi.org/10.1155/2022/3111054 |
work_keys_str_mv | AT gupeng analysisofapparentdiffusioncoefficientvalueanddynamiccontrastenhancedmagneticresonanceimagingparametersofprostatecancerpatientsafterdiagnosisandtreatmentwithmagneticresonanceimaging |