Cargando…

Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging

This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contra...

Descripción completa

Detalles Bibliográficos
Autor principal: Gu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246578/
https://www.ncbi.nlm.nih.gov/pubmed/35785146
http://dx.doi.org/10.1155/2022/3111054
_version_ 1784738996073529344
author Gu, Peng
author_facet Gu, Peng
author_sort Gu, Peng
collection PubMed
description This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scans were performed to determine the shape, scope, and enhancement characteristics of prostate lesions and their relationship with surrounding tissues. The quantitative parameters of ADC and DCE-MRI were measured. There were 4 patients (6.67%) with a Gleason score of 6 and 15 patients (25%) with a 4 + 3 score. The ADC with Gleason = 6 is 0.81 ± 0.08 × 10(−3) s/mm(2), the ADC with Gleason = 3 + 4 is 0.74 ± 0.07 × 10(−3) s/mm(2), the ADC with Gleason = 4 + 3 is 0.73 ± 0.05 × 10(−3) s/mm(2), the ADC with Gleason = 9 is 0.65 ± 0.06 × 10(−3) s/mm(2), and the ADC with Gleason = 10 is 0.59 ± 0.07 × 10(−3) s/mm(2). As the Gleason score increased, the ADC decreased and the permeation parameter transfer constant increased. When the ADC was combined with the permeability parameter transfer constant, the AUC of Gleason = 6 points and Gleason = 7 points was greatly different (P < 0.05). The 95% CI of the ADC combined permeability parameter transport constant when Gleason = 6 points and Gleason = 7 points was 0.898-0.934, the sensitivity was 75.4%, and the specificity was 86.2%. The ADC value was negatively correlated with Gleason score. The ADC value combined with VTC value has good diagnostic performance in evaluating the invasion of PCa, which is very important for making treatment plan and evaluating prognosis.
format Online
Article
Text
id pubmed-9246578
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-92465782022-07-01 Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging Gu, Peng Comput Math Methods Med Research Article This research was aimed at exploring the changes in the apparent diffusion coefficient (ADC) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters of prostate cancer (PCa) patients. Sixty PCa patients from the hospital were recruited as the research object, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) scans were performed to determine the shape, scope, and enhancement characteristics of prostate lesions and their relationship with surrounding tissues. The quantitative parameters of ADC and DCE-MRI were measured. There were 4 patients (6.67%) with a Gleason score of 6 and 15 patients (25%) with a 4 + 3 score. The ADC with Gleason = 6 is 0.81 ± 0.08 × 10(−3) s/mm(2), the ADC with Gleason = 3 + 4 is 0.74 ± 0.07 × 10(−3) s/mm(2), the ADC with Gleason = 4 + 3 is 0.73 ± 0.05 × 10(−3) s/mm(2), the ADC with Gleason = 9 is 0.65 ± 0.06 × 10(−3) s/mm(2), and the ADC with Gleason = 10 is 0.59 ± 0.07 × 10(−3) s/mm(2). As the Gleason score increased, the ADC decreased and the permeation parameter transfer constant increased. When the ADC was combined with the permeability parameter transfer constant, the AUC of Gleason = 6 points and Gleason = 7 points was greatly different (P < 0.05). The 95% CI of the ADC combined permeability parameter transport constant when Gleason = 6 points and Gleason = 7 points was 0.898-0.934, the sensitivity was 75.4%, and the specificity was 86.2%. The ADC value was negatively correlated with Gleason score. The ADC value combined with VTC value has good diagnostic performance in evaluating the invasion of PCa, which is very important for making treatment plan and evaluating prognosis. Hindawi 2022-06-23 /pmc/articles/PMC9246578/ /pubmed/35785146 http://dx.doi.org/10.1155/2022/3111054 Text en Copyright © 2022 Peng Gu. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gu, Peng
Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
title Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
title_full Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
title_fullStr Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
title_full_unstemmed Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
title_short Analysis of Apparent Diffusion Coefficient Value and Dynamic Contrast-Enhanced Magnetic Resonance Imaging Parameters of Prostate Cancer Patients after Diagnosis and Treatment with Magnetic Resonance Imaging
title_sort analysis of apparent diffusion coefficient value and dynamic contrast-enhanced magnetic resonance imaging parameters of prostate cancer patients after diagnosis and treatment with magnetic resonance imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246578/
https://www.ncbi.nlm.nih.gov/pubmed/35785146
http://dx.doi.org/10.1155/2022/3111054
work_keys_str_mv AT gupeng analysisofapparentdiffusioncoefficientvalueanddynamiccontrastenhancedmagneticresonanceimagingparametersofprostatecancerpatientsafterdiagnosisandtreatmentwithmagneticresonanceimaging