Cargando…

Targeting Transporters for Drug Delivery to the Brain: Can We Do Better?

Limited drug delivery to the brain is one of the major reasons for high failure rates of central nervous system (CNS) drug candidates. The blood–brain barrier (BBB) with its tight junctions, membrane transporters, receptors and metabolizing enzymes is a main player in drug delivery to the brain, res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Puris, Elena, Fricker, Gert, Gynther, Mikko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Expert Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246765/ https://www.ncbi.nlm.nih.gov/pubmed/35359241 http://dx.doi.org/10.1007/s11095-022-03241-x

Ejemplares similares

L-Type amino acid transporter 1 as a target for drug delivery
por: Puris, Elena, et al.
Publicado: (2020)

The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy
por: Puris, Elena, et al.
Publicado: (2023)

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery
por: Huttunen, Kristiina M., et al.
Publicado: (2022)

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
por: Gynther, Mikko, et al.
Publicado: (2022)

On The Rate and Extent of Drug Delivery to the Brain
por: Hammarlund-Udenaes, Margareta, et al.
Publicado: (2007)

Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
por: Gynther, Mikko, et al.
Publicado: (2018)

Can we recommend varicocele surgery for men with hypogonadism?
por: Marquardt, Nilson, et al.
Publicado: (2023)

Transvenous Lead Extraction: Do We Need to Explore Alternative Techniques?
por: Ellis, Christopher R.
Publicado: (2019)

Atrial Fibrillation Ablation Without Fluoroscopy: Because We Can
por: Doshi, Rahul N.
Publicado: (2018)

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels
por: Montaser, Ahmed, et al.
Publicado: (2020)

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
por: Puris, Elena, et al.
Publicado: (2022)

l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
por: Huttunen, Johanna, et al.
Publicado: (2019)

Osteoarthritis: Can We Do Better?
por: Collins, Dylon P, et al.
Publicado: (2022)

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
por: Shugarts, Sarah, et al.
Publicado: (2009)

Can we use a biomarker to guide antibiotic treatment in severe COPD exacerbations?
por: Adepoju, Victor A.
Publicado: (2019)

Pregnancy-adapted YEARS algorithm: can YEARS do more for pregnant women?
por: Bokan, Aleksandar, et al.
Publicado: (2020)

Management Strategies for Severe and Refractory Acute Respiratory Distress Syndrome: Where Do We Stand in 2018?
por: Nasim, Rabab, et al.
Publicado: (2019)

Malaria: How Are We Doing and How Can We Do Better?
por: Rosenthal, Philip J., et al.
Publicado: (2019)

Commentary: An Unusual Case of Leadless Pacemaker Implantation in a Patient with Wolff-Parkinson-White Syndrome: Just Because We Can, Does That Mean That We Should?
por: Bhimani, Ashish A., et al.
Publicado: (2017)

Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?
por: Pinheiro, Rúben G. R., et al.
Publicado: (2021)

Pharmacy Internships: We Can Do Better
por: Nisly, Sarah, et al.
Publicado: (2018)

Innovation in Gastroenterology—Can We Do Better?
por: Klang, Eyal, et al.
Publicado: (2022)

Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections
por: Shin, Sooyoung, et al.
Publicado: (2022)

Caring for traumatic brain injury in children can be a challenge!
por: Chen, Chun-Yu, et al.
Publicado: (2011)

Hospital design for better infection control
por: Lateef, Fatimah
Publicado: (2009)

Increasing adverse drug reaction reporting—How can we do better?
por: Potlog Shchory, Miri, et al.
Publicado: (2020)

Rationing care in COVID-19: if we must do it, can we do better?
por: Rockwood, Kenneth
Publicado: (2020)

Topical Drug Delivery to the Posterior Segment of the Eye: Addressing the Challenge of Preclinical to Clinical Translation
por: Rodrigues, Gerard A., et al.
Publicado: (2018)

We can do much better than what we did
por: Lee, Sang-Hak
Publicado: (2020)

Myocardial infarction on the ICU: can we do better?
por: Webb, Ian, et al.
Publicado: (2008)

Diagnosis of latent tuberculosis: Can we do better?
por: Al-Orainey, Ibrahim O.
Publicado: (2009)

Sebaceous gland carcinoma: Can we do better?
por: Honavar, Santosh G
Publicado: (2018)

Terminal Care: How Can We Do Better?
por: Wilkes, Erik
Publicado: (1986)

Oral cancer: We can do better - now
Publicado: (2020)

Cancer in southeast Asia: can we do better?
por: The Lancet Regional Health – Southeast Asia
Publicado: (2023)

Radiologic approach to axial spondyloarthritis: where are we now and where are we heading?
por: Kucybała, Iwona, et al.
Publicado: (2018)

In Vivo Methods to Study Uptake of Nanoparticles into the Brain
por: van Rooy, Inge, et al.
Publicado: (2010)

Current and Future Drug Targets in Weight Management
por: Witkamp, Renger F.
Publicado: (2010)

“Focused Ultrasound-mediated Drug Delivery in Humans – a Path Towards Translation in Neurodegenerative Diseases”
por: Wasielewska, Joanna M., et al.
Publicado: (2022)

One Step Surgery for Cutaneous Melanoma: “We Cannot Solve Our Problems with the Same Thinking We Used When We Created Them?”
por: Tchernev, Georgi
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tc1ddjebs1m4e0nvgbh0aagjl6