Unbound Brain-to-Plasma Partition Coefficient, K(p,uu,brain)—a Game Changing Parameter for CNS Drug Discovery and Development

PURPOSE: More than 15 years have passed since the first description of the unbound brain-to-plasma partition coefficient (K(p,uu,brain)) by Prof. Margareta Hammarlund-Udenaes, which was enabled by advancements in experimental methodologies including cerebral microdialysis. Since then, growing knowle...

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Detalles Bibliográficos
Autores principales: Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246790/
https://www.ncbi.nlm.nih.gov/pubmed/35411506
http://dx.doi.org/10.1007/s11095-022-03246-6

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