Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog

PURPOSE: We have recently demonstrated the brain-delivery of an Amyloid-ß oligomer (Aßo)-binding peptide-therapeutic fused to the BBB-crossing single domain antibody FC5. The bi-functional fusion protein, FC5-mFc-ABP (KG207-M) lowered both CSF and brain Aß levels after systemic dosing in transgenic...

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Detalles Bibliográficos
Autores principales: Lessard, Etienne, Rennie, Kerry, Haqqani, Arsalan, Ling, Binbing, Whitfield, James, Paradis, Andrea, Araujo, Joseph, Yoganathan, Nathan, Gillard, John, Stanimirovic, Danica, Chakravarthy, Balu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246806/
https://www.ncbi.nlm.nih.gov/pubmed/35704250
http://dx.doi.org/10.1007/s11095-022-03285-z

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